Objetivo: O câncer de Brônquio e pulmão (CP) é uma doença altamente letal. Geralmente é detectado em estádios avançados, uma vez que a sintomatologia da doença não é detectada nos estádios iniciais. A população idosa por ter mais tempo exposição a fatores como consumo dos derivados do tabaco, tornan...

Bronchial cancer remains the leading cause of cancer death worldwide due to lack of early diagnosis and difficulties of treatment. This failure of therapeutic strategies is mainly due to the presence of aberrant EGFR mutations and activations leading to exacerbated tumor growth. Despite the evolutio...

Numerous epidemiological studies have demonstrated that chronic PM2.5 exposure was associated with the lung carcinogenesis without known potential mechanisms. Exosomes-derived non-coding RNAs, including miRNAs, are proposed to play critical role in the occurrence and development of malignant disease...

Circular RNAs (circRNAs) have been demonstrated to play critical roles in the pathogenesis of human cancers and carcinogenesis of several environmental pollutants. Nevertheless, the function of circRNAs in cadmium carcinogenesis is unclear. circ-SHPRH is down-regulated in many cancers including non-...

PM2.5 is a harmful air pollutant currently threatening public health. It has been closely linked to increased morbidity of bronchial asthma and lung cancer worldwide. Salidroside (Sal), an active component extracted from Rhodiola rosea, has been reported to ameliorate the progression of asthma. Howe...

Exposure to fine particulate matter (PM2.5) in outdoor air is carcinogenic and associated with the development of lung cancer; however, the underlying mechanism remains unclear. In the present study, the profiles of lncRNA, microRNA and mRNA expression profiles in human bronchial epithelia (HBE) fol...

23rd European Conference on General Thoracic Surgery, Lisbon, PORTUGAL, ă MAY 31-JUN 03, 2015 International audience To determine contemporary early outcomes associated with bilobectomy for ă lung cancer and to identify their predictors using a nationally ă representative general thoracic surgery da...

Each human cell contains a genome carrying all the genetic information necessary for the constitution of the whole organism. However, differentiated cells express only a restricted repertoire of genes. The control of gene expressions is fundamental for the establishment and maintenance of cell ident...

Ground-glass opacity (GGO) is defined as an opacity that does not obscure underlying bronchial structures or pulmonary vessels at high-resolution computed tomography (CT). GGO is a rather unspecific radiologic feature seen in a number of clinical conditions involving different pathologic processes....

Arsenic and benzo[a]pyrene (BaP) are among the most common environmental carcinogens causing lung cancer. Millions of people are exposed to arsenic through consuming arsenic-contaminated drinking water. High levels of BaP are found in well-done barbecued meat and other food in addition to cigarette...

Background: Diesel engine exhaust (DEE) exposure causes lung cancer, but the molecular mechanisms by which this occurs are not well understood. Objectives: To assess transcriptomic alterations in nasal epithelium of DEE-exposed factory workers to better understand the cellular and molecular effects...

Introduction: Inhalation of asbestos induces lung cancer via different cellular mechanisms. Together with the increased production of carbon nanotubes (CNTs) grows the concern about adverse effects on the lungs given the similarities with asbestos. While it has been established that CNT and asbestos...

When considering three-dimensional conformal radiotherapy for non-small cell lung cancer, the uncertainties about treatment can be quite significant, due to set-up errors and organ or tumor motion. These can be important causes of treatment failure. Immobilization devices have only been studied rece...

During my PhD, I have been interested in the role of the innate immune receptor NLRP3, a key component of the inflammasome, in lung cancer development. Our results show the presence of a functional NLRP3 inflammasome in normal human bronchial epithelial cells (HBEC). Surprisingly, NLRP3 expression is...

Chronic arsenic exposure is associated with the increased risk of several types of cancer, among which, lung cancer is the most deadly one. Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription factor belonging to CNC-bZIP family, regulates multiple important cellular functions in response to...

To assess the carcinogenic potential of PM2.5 exposure, we developed a cell-based experimental protocol to examine the cell transformation activity of PM2.5 samples from different regions in China. The seasonal ambient PM2.5 samples were collected from three megacities, Beijing (BJ), Wuhan (WH), and...

Excessive concentrations of smog toxicants constitute a critical factor influencing the health quality of inhabitants of urban agglomerations. The exposure to elevated concentrations of sus-pended particulate matter, sulfur dioxide (SO2), nitrogen dioxide (NO2) and carbon monoxide (CO) is associated...