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Chemical characterization of exudates, and study of the proteomic response from two marine phytoplankton species exposed to trace metals : the diatom Skeletonema costatum and the toxic dinoflagellate Alexandrium catenella
Mpact of several trace metals (lead, zinc, copper or cadmium) on the growth of two marine phytoplankton species: the diatom Skeletonema costatum and the toxic dinoflagellate Alexandrium catenella, has been studied from cultures grown under physiological and contaminated conditions. The results obtai...
One-carbon metabolism ans smoking related cancers
B-vitamins and factors related to one-carbon metabolism (OCM) pathway help to maintain DNA synthesis and regulate gene expression and may affect cancer risk. The overarching aim of this thesis is to investigate the importance of OCM biomarkers in the etiology of three distinct cancer sites that diff...
Implicación de las modificaciones de tRNA y del metabolismo de los folatos en la respuesta inmune de Arabidopsis
Throughout evolution, plants have developed a sophisticated network of signaling pathways allowing the activation and regulation of immune responses. The identification of metabolic pathways which are involved in modulating the intensity of that immune responses is an important challenge in the fiel...
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
OBJECTIVE: Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cho...
Radial pulse spectrum may be a predictor of ischemic heart disease in patients with type 2 diabetes
Ischemic heart disease (IHD) contributes to a high percentage of morbidity and mortality of diabetes. A predictor of IHD can lead to an early diagnosis to prevent progression and to reduce future clinical events. The aim of the study was to examine whether the spectrum analysis of radial pressure wa...
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Hypertension In A Patient With Spinal Cord Trauma : Can Clevidipine Be An Option?
BACKGROUND: Clevidipine is an arterially selective dihydropyridine calcium channel blocker with a half-life of approximately 1 minute. It demonstrates rapid onset and offset of blood pressure-decreasing effect, allowing for responsive titration and a decreased risk of overshoot hypotension. Addition...
Synthesis and pharmacological evaluation of preactivated ifosfamide analogs : prodrugs and nanoparticles designed against cancer.
Ifosfamide (IFO) and cyclophosphamide (CPM) are oxazaphosphorines, prodrugs requiring bioactivation to be active. Regarding IFO, its biotransformation leads to a low release of the active hydroxylated compound with associated toxic side effects. Preactivated IFO analogs with saturated or unsaturated...
Biodegradation of phenol by a highly tolerant strain Rhodococcus ruber C1: Biochemical characterization and comparative genome analysis
A novel phenol-degrading strain was isolated and identified as Rhodococcus ruber C1. The degradation analysis shows that 1806 mg/L of phenol can be completely degraded by strain C1 within 38 h, and the maximum specific growth rate (μmax=1.527 h−1) and maximum specific phenol degradation rate (qmax=3...
Climate change and vegetation dynamics in the Andes of central Chile since the mid-twentieth century : the case of Yerba Loca valley
The term folate (vitamin B9) is a family of molecules with a basic structure composed of 3 parts: a core pterin, a para amino benzoic acid (PABA) moiety and a chain of glutamate. The role of these cofactors is to carry one-carbon groups. They are involved in many reactions such as the synthesis of n...
Anthelmintic Activity of Curcuma Aeruginosa Roxb Extract on Fasciola gigantica in Vitro
Fasciola gigantica is a parasite that causes a disruption of the metabolism of fats, proteins, and carbohydrates, which interferes growth and causes death. Curcuma aeruginosa Roxb extract is one of the medicinal plants which has been used to treat several diseases. The aim of this study was to deter...
Data from: Toward a periodic table of niches, or exploring the lizard niche hypervolume
Widespread niche convergence suggests that species can be organized according to functional trait combinations to create a framework analogous to a periodic table. We compiled ecological data for lizards to examine patterns of global and regional niche diversification, and used multivariate statisti...
Prognostic and predictive biomarkers of the severity of bradykinin-mediated angioedema
The heterogeneous clinical manifestations and the unpredictable nature of C1-INH-HAE require the identification of biomarkers and the development of accompanying bioassays. To contribute to this purpose this thesis focused on four topics:I. The expression of bradykinin receptors. B1R and B2R are pot...
HAD hydrolase function unveiled by substrate screening: enzymatic characterization of Arabidopsis thaliana subclass I phosphosugar phosphatise AtSgpp
Deciphering the evolution characteristics of extracellular microbial products from autotrophic and mixotrophic anammox consortia in response to nitrogen loading variations
Extracellular microbial products (EMP) in biological wastewater treatment systems vary with operational conditions and in turn indicate the metabolic status of functional bacteria. In this study, the response of EMP from autotrophic and mixotrophic anammox consortia (AAC and MAC) to the variation of...
Heterologous Grafting Improves Cold Tolerance of Eggplant
Grafting is commonly used to enhance the quality and confer biotic or abiotic stress tolerance to plants. There is, however, no clear understanding of how grafted eggplant responds to cold stress. Here, four grafting combinations of eggplant from cold-sensitive line J55 and cold-resistant line J65 w...
Biochemical metabolism of mammalian seedlings under saline stressing
Objetivou-se com presente trabalho, avaliar o metabolismo bioquímico de plântulas de mamoeiro submetidas a diferentes níveis de salinidade, e cultivados e três tipos de substratos, a fim de determinar qual substrato promoveu um melhor ajustamento osmótico ao estres salino. Para produção das mudas da...
Special issue "Microbial one-carbon metabolism of natural and engineered systems"
International audience The goal of this Special Issue will be to provide a broad overview of the recent breakthroughs and current questions in the dynamic field of microbial C1 metabolism, as a crucial component of the biogeochemical processes of the planet in the Anthropocene. Contributions will ra...
Dynamics of soybean leaf hydraulic conductance and diurnal soybean transcriptome analysis
Leaves must remain hydrated with a constant flow of water through the leaf if stomata are to remain open for CO2 acquisition during the day. Thus, leaf hydraulic conductance (Kleaf), a measure of the leaf’s capacity to transport water to the sites of evaporation within the leaf, is closely linked an...
Transcriptional regulatory elements for basal expression and effects of phenobarbital and dexamethasone onmRNA levels of rabbit CYP2C genes
Cytochrome P450 (CYP) genes, expressed in many species, are involved in the oxidative metabolism of many xenobiotis as well as endogenous compounds. Expression of the rabbit CYP2C1 gene is observed only after induction with phenobarbital and is confined to the liver. The CYP2C2 gene is inducible in...
Fractionation, molecular composition, and biological effects of organic matter in bio-stabilization sludge with implication to land utilization
Bioactive organic compounds (BOCs) contained in bio-stabilized products of waste activated sludge (WAS) have attracted considerable attention, as they can enhance the fertilizing effect of WAS in land applications. This study investigated the molecular composition and plant-growth-promoting mechanis...