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Study of the molecular mechanisms of malignant melanoma differential resistance to vinca alkaloids
Malignant melanoma (MM) is a very refractory tumor to anticancer therapies, including vinca alkaloïds (VAs). To investigate the role of GSTM1 (glutathione S-transferase μ1) and MRP1 (multidrug resistance protein 1) in MM acquired resistance to VAs, we established 4 cellular models of resistance to v...
YouTube Video Analysis
Seyahat edenler, destinasyon tercihlerinde sosyal medya sitelerindeki fotoğraf, video veya yazılı paylaşımlardan etkilenmektedirler. Dünyada ve Türkiye’de İnanç turizmi kapsamında ziyaret edilen birçok nokta bulunmaktadır. Sosyal medyanın pazarlama gücünden yararlanarak daha az bilinen inanç turizm...
Seasonal fluctuations of bacterial community diversity in agricultural soil and experimental validation by laboratory disturbance experiments.
Natural fluctuations in soil microbial communities are poorly documented because of the inherent difficulty to perform a simultaneous analysis of the relative abundances of multiple populations over a long time period. Yet, it is important to understand the magnitudes of community composition variab...
Pengembangan Modul Berbasis Problem Based Learning untuk Meningkatkan Kemampuan Berpikir Kritis Siswa Berdasarkan Hasil Penelitian Analisis Cluster Persilangan Kedelai Tahan CpMMV
Abstract: This study aims to develop a PBL-based module that is valid, practical and effective, based on the results of the CpMMV resistant soybean hybridization cluster analysis research. Modules are developed using the ASIE instructional design model. Data was collected using validation questionna...
Trends in Ecosystem Services across Europe Due to Land-Use/Cover Changes
The growing pressure on society due to global change requires better integration of ecosystem services (ES) into decision-making. Despite a growing number of ES assessments, Europe-wide information on recent changes of multiple ES is still rare. This study aimed at analysing changes in ES values bet...
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Seasonal and spatial assessment of the surface water quality of the Longá river basin, Piauí, Brazil
Este artigo teve como objetivo avaliar a qualidade das águas superficiais da bacia hidrográfica do rio Longá no Estado do Piauí, Brasil. Sete pontos foram monitorados, com base na proximidade de estações meteorológicas e acessibilidade, para obter melhores caracterizações espaciais e de ocupação da...
Fluid escape features as relevant players in the enhancement of seafloor stability?
Fluid migration within the sedimentary column contributes significantly to slope failure and pockmark formation and can be an effective triggering mechanism to generate submarine landslides. Pockmarks are thus commonly listed among geohazards. Contrary to these accepted notions, we propose here an a...
Men, power and conflict: Studies on the South American colonial border and its crisis
El libro comienza su introducción con un trabajo de Juan Marchena quien indaga en larga duración las repercusiones que tuvieron los conflictos hispanolusitanos de la península en el plano americano, desde el Amazonas hasta el Río de la Plata. Así, este trabajo permite adentrarnos en el otro plano de...
Modeling Online Reviews with Multi-grain Topic Models
In this paper we present a novel framework for extracting the ratable aspects of objects from online user reviews. Extracting such aspects is an important challenge in automatically mining product opinions from the web and in generating opinion-based summaries of user reviews. Our models are based o...
Understanding the Behaviour of Olive Oil Tourists: A Cluster Analysis in Southern Spain
Olive oil tourism is a recent development in the countries of the Mediterranean basin, but it is now spreading to other regions of the world. The main reasons people are choosing this special interest tourism (SIT) are to find out about the culture surrounding olive oil and to enjoy the whole host o...
Design of Intelligent Walking Stick for the Elderly based on User Experience Research
Purpose: Using the design ideas and research methods of user experience to probe into design art in the field of the elderly products, thus presenting an innovative intelligent walking stick with a better user experience. Methods: Questionnaire surveys, observation, interviews and other methods were...
China’s Water Utilization Efficiency: An Analysis with Environmental Considerations
This paper estimates China’s water utilization efficiency using the directional distance function to take into account the environmental degradation affecting the economy. We further analyze the spatial correlation and the factors influencing the utilization efficiency using spatial panel data model...
Network-wide intrusion detection through statistical analysis of event logs : an interaction-centric approach
Event logs are structured records of all kinds of activities taking place in a computer network. In particular, malicious actions taken by intruders are likely to leave a trace in the logs, making this data source useful for security monitoring and intrusion detection. However, the considerable volu...
Cluster analysis and geochemical processes for the characterization of the aquifer system in Maracanã/São Luis/MA
ABSTRACT To better know the aquifer system in the Maracanã Environmental Protection Area were collected samples in four campaigns; the first during the drought season and the others in the following rainy one. The water samples were analised for eleven hydrochemical parameters, CE, Ca2+, Mg2+, Na+,...
PROTOCOL: Strengthening women's empowerment and gender equality in fragile contexts towards peaceful and inclusive societies: A systematic review and meta‐analysis
Abstract This review builds on 3ie's (international initiative for impact evaluation) evidence gap map (EGM) of the impact evaluation and systematic review (SR) evidence base of interventions aiming to promote peaceful and inclusive societies in fragile contexts. The EGM identified a cluster of stud...
Value Chains of Carrot Commodity on Suthomadansih Agropolitan Area in Karanganyar Regency
In 2007, Central Java Government has been starting the implementation of agropolitanprogram in some regency that has the potential in the agriculture sector, Karanganyar Regency one of them. Through this program, SuthomadansihAgropolitan Area was established. One of the leading commodities from Suth...
An Analysis of the Role of Local Residents’ Destination Image and Perceived Effects of Tourists on Rural Tourism Sustainable Development
This study aims to investigate the role of Destination image and the perceived effects of local residents and tourists in the tourism development of the rural tourism region of Babolsar. The present study is an applied research in terms of purpose and it is a descriptive-correlation study. The popul...
Exact algorithms for size constrained clustering
Clustering or cluster analysis  is a method in unsupervised learning and one of the most used techniques in statistical data analysis. Clustering has a wide range of applications in many areas like pattern recognition, medical diagnostics, datamining, biology, market research and image analysis a...
Analysis of cluster restructuring at Oran University Hospital, Algeria
`titrebAnalysis of activity pole restructuring at Oran University Hospital, Algeria`/titrebAim: The EHUO project of reorganization of medical units into the new activity poles is a complex exercise and a challenge in relation to structural, organizational, and especially cultural barriers. The relat...
Educational paths of young women and men. An approximation from the analysis of sequences
Sobre la base de la Encuesta a la Juventud de Cataluña 2012, en este artículo se define una tipología de trayectorias educativas de los jóvenes para discernir cuáles son los factores que determinan los itinerarios académicos y en qué medida existen desigualdades significativas de género. Mediante el...
Analyzing the voting cluster of political parties: A case study of Lahore district (1970-2013)
A voting cluster is a connotation that denotes party loyalty rather than ethnic and social cleavages. The theory of voting cluster surfaces when the units of analysis are characterized by political parties and the voter instead of their nomenclatures. This makes this study significant and different...
Internal structures and external connectedness: towards a typology of French clusters
International audience This explorative study aims at appraising the relationship between clusters’ internal structures and pipeline-building practices. We adopt a knowledge-centred perspective on clusters and investigate whether clusters’ structural diversity explains external (knowledge) collabora...
Characterisation of transposable mariner like elements in marine diatoms
Transposable elements (TE) are sequences able to move between two loci in the host genomes. Mariner-like element (MLE) are well characterized in animal and land plant genomes but not in marine microalgae. In this work, we have looked for MLE in marine diatoms (Bacillariophyceae) that are microalgae...
Typology and differentiation of guayaba producers (Psidium guajava L.) in Calvillo, Aguascalientes, Mexico
En este trabajo se realizó la tipología de los productores de guayaba en Calvillo, Aguascalientes, México, con información obtenida de las 91 encuestas que se les aplicaron. Mediante el análisis de conglomerados y el discriminante se conformaron tres tipos de productores: tradicionales (54 por cient...
Assessment of rainfall heavy metals in the Bojnourd urban watershed
Background and Objective: Important information can be obtained about the sources of pollutants in the atmosphere by studying the concentration of heavy metals in atmospheric precipitation.. Therefore, in this study concentrations of Pb, Zn and Cu were measured in samples of urban watershed of Bojno...