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Function and dysfunction of active efflux systems in clinical strains of pseudomonas aeruginosa
Pseudomonas aeruginosa is a nosocomial pathogen naturally resistant to many antibiotics thanks to numerous resistantmechanisms. Among them, overproduction of the MexXY/OprM efflux System leads to decrease significantly thesusceptibility of P. aeruginosa to aminoglycosides, fluoroquinolones and some...
Deconstructing migration paradigms through studies on the emigration and immigration of women in Italy
Research on Italian emigrants and immigrants has evolved in the same epistemic space, asked the same questions and provided complementary answers that allow progress to be made in gene-migration studies based on three findings. The first is that the complexity of migration flows is a process that is...
Photosynthesis down-regulation precedes carbohydrate accumulation under sink limitation in Citrus
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Cellular and molecular oncology
Education Introduction The regulation of gene expression is an essential aspect of cancer transformation. In the rest of the previous year’s teaching on key regulation of cell stress (P53), this year’s teaching focused on the historical case of nuclear receivers. The transcription of genes is the su...
Argudas: arguing with gene expression information
In situ hybridisation gene expression information helps biologists identify where a gene is expressed. However, the databases that republish the experimental information are often both incomplete and inconsistent. This paper examines a system, Argudas, designed to help tackle these issues. Argudas i...
Molecular mechanisms involved in the horizontal transfer of the multidrug resistance genomic island Salmonella Genomic Island 1
The Salmonella genomic island 1 is an integrative mobilizable element (IME) originally identified in epidemic multidrug-resistant Salmonella enterica Typhimurium DT104. The occurrence of SGI1 in several S. enterica serovars and recently in Proteus mirabilis has led to demonstrate its horizontal tran...
Analysis of the suppressive RNA silencing protein of the yellow vein virus of pepper 5 (PeVYV-5)
[ES] RNA silencing is a sequence specific gene regulation system that is highly preserved in eucalariots. In plants, this mechanism plays a very important role vis-à-vis exogenous nucleic acids such as transgenes or viral agents. Viruses generate, at some stage of their replication cycle, dual chain...
Genetic study of glycemic control
Type 2 Diabetes is a major health care problem responsible for early morbidities and mortality. T2D prevalence inexorably increases due to dramatic changes in our way of life. T2D is preventable but no generally curable and present medications fail to prevent the worsening of glucose control and the...
Pysiopathology and therapeutic approaches for TMD and LGMD2J
Titin is a giant protein expressed in both skeletal muscles and heart. Several pathogenic mutations were identified in its last coding exon. The most frequent mutation commonly referred to as FINmaj, results in the replacement of 4 amino acids and affects a subset of patients in Finland. The mutatio...
Pharmacogenomic and High-Throughput Data Analysis to Overcome Triple Negative Breast Cancers Drug Resistance
Given the large number of treatment-resistant triple-negative breast cancers, it is essential to understand the mechanisms of resistance and to find new effective molecules. First, we analyze two large-scale pharmacogenomic datasets. We propose a novel classification based on transcriptomic profiles...
The role of Legionella pneumophila efflux pumps in biocides and host’s resistance
Bacterial multi-drug resistance is of major concern in the case of clinic. One of the resistance mecanisms used by bacteria is the efflux of noxious compounds out of the cell thanks to inner membran proteins called efflux pumps. This proteins belong to five families (MFS, RND, MATE, SMR and ABC) and...
Novel antiviral mechanism of IFN-stimulated gene 20(ISG20) via translational suppression
Interferons specify a complex antiviral response that upon the detection of pathogens through various cellular pattern-recognition receptors (PRRs) lead to the induction of hundreds of genes named interferon-stimulated genes (ISGs). Several ISGs have been reported to restrict viral infection, howeve...
Combined effects of PPARγ2 P12A and PPARα L162V polymorphisms on glucose and insulin homeostasis : the Québec Family Study
Peroxisome proliferator-activated receptors γ2 and α are nuclear factors known to be important regulators of lipid and glucose metabolism. Two polymorphisms, namely PPARγ2 P12A and PPARα L162V, were investigated for their individual and interaction effects on glucose and insulin homeostasis. Genotyp...
Characterization of Vitis vinifera PR10 genes and analysis of their expression during somatic embryogenesis
The objective of my work was to analyse the somatic embryogenesis process of Vitis vinifera at a molecular scale. Thus, the expression of genes implied in development or defence, especially PR10 genes, was monitored during the key-steps of entrance and exit of secondary somatic embryogenesis. The co...
Functional characterization of the rice transcription factors OsMADS25 and OsMADS26 in regard to development and biotic and abiotic stresses resistance
MADS-box transcription factors (TF) have been mostly characterized for their involvement of plant development such as floral organogenesis and flowering time. Some of them are involved in stress related developmental processes such as abscission, fruit ripening and senescence. Overexpression of the...
Impact of a feminizing endosymbiotic bacteria (genus Wolbachia) on the evolution of terrestrial isopods sex chromosomes
Oniscidea show a remarkable diversity of chromosomal sex determination systems (male heterogamety XX/XY or female heterogamety ZW / ZZ). However, the origin of such diversity is still largely unknown to date. It has been proposed that these different systems may be the product of the coevolution bet...
Cross resistance of Brassica spp. against vascular pathogens, Fusarium oxysporum f.sp. conglutians, Verticillium longisporum and Xanthomonas campestris pv. campestris
[EN] Fusarium oxysporum f. sp. conglutinans (FOC) is an important soil-borne fungus that causes vascular wilt disease in Brassica crops, resulting in severe losses in both yield and quality. However, crop rotation and fungicide application are not effective to manage this disease due to the difficul...
Currently used pesticides and their mixtures : what are the risks to non-target aquatic organisms? Laboratory and in situ approaches.
Pesticides have enabled humankind to protect its crops from pests, intensifying thus the crop yields to sustain the growing population. However, pesticides often end up in aquatic water bodies, e.g. via field runoff, where they may harm non-target organisms. The environmental concentrations of pesti...
Multiple regulators mediate the transcriptional activities of ERRalpha and its capacity to promote cell invasion
ERRα is a nuclear receptor whose activity mainly depends on its interaction with transcription co-regulators. High levels of ERRα are found in various cancer types and correlate with poor prognosis. However, the mechanisms linking ERRα to cancer cell migration as well as the coregulators involved ar...
Sistema DE cultivo PARA mejorar LA Viabilidad DE EMBRIONES BOVINOS producidos IN VITRO
Murillo Ríos, AV. (2018). SISTEMA DE CULTIVO PARA MEJORAR LA VIABILIDAD DE EMBRIONES BOVINOS PRODUCIDOS IN VITRO [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/111541
Dose and cofactors of Hox proteins during flight organs development of insects
During evolution, animais have developed an astonishing morphological diversity, allowing them to adapt to a wide variety of environments. One of the most striking examples is the radiation of flight appendages in insects, starting from ancestors with two similar pairs of wings. Severa! studies show...
Effect of apoC-III gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men
Abdominal visceral adipose tissue (AT) accumulation is associated with an atherogenic metabolic profile that includes increased plasma triglyceride (TG), low HDL cholesterol levels, and an insulin-resistant hyperinsulinemic state. Whereas the apolipoprotein (apo) C-III C3238G gene variant, often ref...
Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an unexpected function of FMRP in modulating the activity of Adenosine Deaminase Acting on RNA (ADAR) enzymes has been reported both...
MODY mutations specifically affect the mitotic chromatin localization of HNF1beta
HNF1beta is a POU transcription factor that is frequently mutated in patients that suffer from diabetes and renal cystic dysplasia. This protein has the peculiar ability to bind mitotic chromosomes and behave as a gene bookmarking. Here we show that the capacity of HNF1beta to bind to DNA plays an e...
Production and biotechnological use of new anti-fungal proteins from filamentary fungi
Antimicrobial peptides (AMP) are a promising alternative for the development of new antifungics that can replace fungicides used in agriculture. However, the high cost of chemical synthesis and the difficulty of producing it on a large scale have limited its implementation. Antifungal proteins (AFP)...