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c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.
Background: Inhibition of the c-Jun N-terminal kinase (JNK) pathway by the TAT-coupled peptide XG-102 (formerly D-JNKI1) induces strong neuroprotection in ischemic stroke in rodents. We investigated the effect of JNK inhibition in intracerebral hemorrhage (ICH). Methods: Three hours after induction...
Protective effect of intrastriatal grafts in an experimental Huntington disease model. Behavioural and morphological correlation (Protective effect of intrastriatal Grafts in an expert model of Huntington’s disease. Behavioral and Morphological correlationship].
The intrastriatal injection of the excitotoxin quinolinic acid (Q.A.) in rats produces neuroanatomical and neurochemical changes mimicking those appearing in the striatum in Huntington's disease (H.D.). Although its cause is unknown, it has been hypothesized that the neurodegenerative changes seen i...
Reversible neurochemical changes mediated by delayed intrastriatal glial cell line-derived neurotrophic factor gene delivery in a partial Parkinson's disease rat model.
The role of C-Jun N-terminal kinase in a mouse model of intracerebral hemorrhage
Background: Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by a haematoma within the brain parenchyma resulting from blood vessel rupture and with a poor outcome. In ICH, the blood entry into the brain triggers toxicity resulting in a substantial loss of neurons and an inflammat...
Clinical and Experimental Cell Therapy in Parkinson’s Disease
Parkinson’s disease (PD), a chronic neurodegenerative disorder, is characterized as a movement disorder with resting tremor, dyskinesia, gait disturbance, etc. The main pathology is based on the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. These motor symptoms ca...
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Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence.
Administration of the neurotoxin 6-hydroxydopamine (6-OHDA) to rat brain causes biochemical and neuroanatomical changes to the nigrostriatal dopaminergic pathway similar to those observed in Parkinson's disease (PD). Although the cause of PD is unknown, it has been hypothesized that the neurodegener...
Data for: Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits
This dataset contains all data for published figures and supplementary figures in the manuscript "Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits". GraphPad Prism files can be viewed...
Control of microglial activation by T-cells in a murine model of 6-OHDA-induced dopaminergic neurodegeneration
This thesis work describes and analyzes the neuroinflammatory reaction that accompanies neuronal cell death in a murine model of Parkinson's disease. In this model, induced by the intrastriatal injection of 6-hydroxydopamine (6-OHDA), a toxic dopamine analog, we report on the main features and kinet...
Cell therapy in Parkinson’s disease : intranigral versus intrastriatal transplantation
Parkinson’s disease (PD) is a neurodegenerative disorder associated with a progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN), leading to a loss of dopamine in the striatum. One of the experimental therapeutic approaches in PD is the graft of DA neurons not in their ontogenic...
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system.
The dopamine (DA) transporter (DAT) is a plasma membrane glycoprotein expressed in dopaminergic (DA-) cells that takes back DA into presynaptic neurons after its release. DAT dysfunction has been involved in different neuro-psychiatric disorders including Parkinson's disease (PD). On the other hand,...
Sirtuin 1 activation : a neuroprotective strategy for in vivo cerebral oxidative stress ? Involvement of SIRT1 in the beneficial effects of poly(ADP-ribose)polymerase inhibition
Oxidative stress (OS) is involved in cerebral ischemia and traumatic brain injury and results in deleterious activation of poly(ADP-ribose)polymerase (PARP), an NAD+-dependant enzyme. PARP is implicated in neurological deficit and brain injury post-ischemia and post-trauma. In vitro, PARP overactiva...
Involvement of D²-receptors in the task of labyrinthe radial win-stay in rats
Une injection intrastriatale de l'agoniste D2 quinpirole facilite l'apprentissage de la tâche de labyrinthe radial win-stay (Packard et White, 1991). Trois expériences sont effectuées pour approfondir l'étude de l'implication des récepteurs dopaminergiques D2 dans ce type l'apprentissage et aussi po...
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Injection of excitotoxins, such as quinolinic acid (QA), into the striatum has been extensively used as an experimental model of Huntington's disease, while injection of 6-hydroxydopamine (6-OHDA) into the dopaminergic nigrostriatal pathway provides a well established model of Parkinson's disease. I...
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of the dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although various treatments are successfully used to alleviate the symptoms of PD, none of them prevents or halts the neurodegenerati...
Intensive blood PRESSURE lowerings HEMATOMA Volume IN Experimental Intracerebral HEMORRHAGE
Background and AimsBlood pressure is often elevated in the acute phase of intracerebral hemorrhage (ICH) and linked with a poor outcome. Recent clinical trials provided mixed results on whether intensive blood pressure lowering after ICH is safe and effective in terms of reducing mortality and impro...
Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum.
Injection of quinolinic acid in the rat striatum mimics neurochemical changes observed in Huntington's disease. We previously demonstrated that intrastriatal transplantation of fetal striatum or gelfoam protects against toxicity induced by a subsequent intrastriatal injection of quinolinic acid perf...
Striatal implants of fetal striatum or gelfoam protect against quinolinic acid lesions of the striatum.
Previous studies in our laboratory have shown that intrastriatal implants of fetal striatum significantly attenuate excitotoxic damage resulting from a 240 nmol quinolinic acid (QA) challenge delivered 7 days later. In contrast, animals with intrastriatal implants of other tissue types (adipose tiss...
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Injection of the excitatory amino-acid analog quinolinic acid into the striatum of rats produces neuropathological and neurochemical alterations that are reminiscent of those observed in Huntington's disease. In the present study, we evaluated quinolinic acid-induced striatal changes using quantitat...
Involvement of striatal cholinergic interneurons in the pathophysiology of Parkinson's disease : optogenetics, pharmacological and behavioral approaches
Parkinson’s disease (PD) is characterized by a dopamiergic loss into the striatum, a subcortical structure involved in motor control, memory and emotional behaviors. Striatal cholinergic interneurons (ChIs) play a key role in this pathological reorganization of the striatal circuitry by modulating s...
Relationship between L-dopa induced dyskinesia and the dopamine D1 receptor in striatal neurons : experimental study and perspectives in therapeutic
In my thesis work, I studied the role of dopamine D1 receptor in L-dopa induced dyskinesia, a debilitating complication of Parkinson's disease’s treatment. In condition of striatal denervation, that mimics the Parkinson's disease environment, chronic treatment with L-dopa leads to major alterations...
Study of the pair Netrin-1/DCC in Parkinson's diseas
The secreted protein netrin-1 has diverse functions among which guidance and survival of neurons when bound to its dependence receptor DCC. In the absence of netrin-1, DCC is cleaved and actively triggers cell death in various contexts. DCC is highly present in a subset of mature neurons that typica...
Modulation effects of SK and KV4 potassium channels on motor and cognitive deficits of Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disease associated to a loss of dopaminergic nigrostriatal pathway that innervates the basal ganglia (GB). The DA neuron degeneration in PD induces imbalance between dopaminergic transmission, GABAergic and glutamatergic resulting in impaired neuronal...
Evaluation of potential neuroprotective molecules in an in vivo rat neuroinflammatory model : mechanistic study and time characterization
Neuroinflammation is a key part of the physiopathology of neurodegenerative diseases and is an interesting target in their treatment. In this PhD work, we studied the effects of two potentially anti-inflammatory and neuroprotective molecules, hemin and C16, in an in vivo rat model of neuroinflammati...
The C-Jun N-Terminal Kinase Inhibition in Intracerebral Hemorrhage
Background: In intracerebral hemorrhage (ICH), a subtype of stroke, the bloodentry into the brain triggers toxicity resulting in a strong loss of neurons andinflammation. Water content is also increases leading to growing intracranial pressure,which worsens neurological outcome. C-Jun N-terminal kin...
Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease
Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approach in both an in vitro and in vivo model of PD, we...