Query : Microspectroscopie Raman
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Monitoring of the experimental fusion of Melle galene (79) by microspectroscopy Raman
This paper focuses on the study (macroscopic and microscopic) of the transformation of classic silver ore (galena: PbS) and its evolution from a repository produced experimentally in a muffle furnace operating at charcoal. While the chemical reaction that leads from the sulfide lead bullion is ident...
Molecular alterations of bone composition and structure upon bisphosphonates uptake
Biphosphonates are known for their anti-resorptive effects in benign (osteoporosis) and malignant bone diseases (myeloma, bone metastasis). Their clinical properties are based on the net increase of bone mass and mineral density. Their strong affinity for biominerals allows them a targeting for spec...
Development of a method of detection and quantification of advanced glycation end-products by Raman spectroscopy.
In the context of an aging population and an increase in age-related chronic diseases, the study of protein non-enzymatic glycation constitutes a topical research axis. Indeed, the advanced glycation products (AGE) play an important role in the complication of age-related diseases such as diabetes....
New biomarkers of in vitro cell electropermeabilization and ofskin toxicities in cancer patients using non-invasive and label-freeoptical techniques (Raman microspectroscopy and terahertzmicroscopy)
This research work reports the use of various biophotonics techniques to investigate biomedical questions, from basic research (interaction between pulsed electric fields and cells) to clinical studies (skin toxicity induced in patients treated with targeted anticancer therapies).Confocal Raman micr...
CARS microspectroscopy applied to monitoring the receptor activation associated with the carcinogenesis
Vibrational microspectroscopy is a rapidly emerging label-free technique that allows the probing of live cell. Thanks to the vibration of the chemical bonds, it makes it possible to locate in the cell biomolecules (proteins, nucleic acids, lipids) associated with organelles. My study consisted in us...
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Colouring materials in technical and symbolical systems during Neolithic in Liguro-provençal area
The aim of this research was to determine the “chaînes opératoires” of colouring materials in the north-western Mediterranean region during the Early and Middle Neolithic and to integrate them in chrono-cultural framework. Two major archaeological sites were selected: Castellar – Pendimoun rock-shel...
Vibrational microspectroscopy as a tool for characterising human and reconstructed normal skin: application to psoriatic skin
Research in the field of bioengineered skin substitutes is motivated by the need to find new dressings for people affected by skin injuries (burns, diabetic ulcers), and to develop adequate skin models to test new drug formulations developed in vitro. It is possible to produce human skin substitutes...
The red is placed: analysis of red in the ‘big fire’ earthenware of the xviiia and the 19th century (with the red of Thiviers)
The instability of the iron oxides make it very difficult to obtain the colour red in single- fired faïence. In this experiment, various samples of archaeological faïence from the 18th and 19th centuries were analysed (BSE images by SEM and Raman spectrometry). Before the 1760’s, the results obtaine...
Study of the orientation and crystalline structure of polydioxanone
Le polydioxanone est un polymère cristallin et bioabsorbable qui a été développé pour une utilisation médicale, spécifiquement pour la réalisation de points de sutures. Il présente une meilleure combinaison de propriétés mécaniques (souplesse, résistance et extensibilité) par rapport à d'autres fibr...
Study of skin aging by vibrational microspectroscopy : shedding light on alterations of dermal type I collagen
Skin is a particular organ of the body whose the main function is a protective role towards the external environment. This function is provided by the structure of skin tissues in three layers (epidermis, dermis, hypodermis). The dermis is responsible for the strength and elasticity of the skin. The...
Development of a high-performance UV polymerisable finishing system
Coatings for wood flooring, applied on the wood surface to enhance its durability, undergo numerous mechanical stresses during their lifetime. Among the various damages (chemical, mechanical, environmental) that coatings have to resist to, mechanical damages are the most problematic. Mechanical dama...