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Opinion in response to the HCB referral — case C/NL/06/01_001. Paris, 17 October 2018
Le Haut Conseil des biotechnologies (HCB) a été saisi le 14 août 2018 par les autorités compétentes françaises (le ministère de l’Agriculture et de l’Alimentation) d’une demande d’avis relative au dossier C/NL/06/01_001 de demande de renouvellement d’autorisation de mise sur le marché de la lignée d...
Evidence that the relations between novelty-induced activity, locomotor stimulation and place preference induced by cocaine qualitatively depend upon the dose: A multiple regression analysis in inbred C57BL/6J mice
Reduced fixation on the upper area of personally familiar faces following acquired prosopagnosia
Selective impairment of face recognition following brain damage, as in acquired prosopagnosia, may cause a dramatic loss of diagnosticity of the eye area of the face and an increased reliance on the mouth for identification (Caldara et al., 2005). To clarify the nature of this phenomenon, we measure...
Veterinary pharmacology and toxicology
Mornet Paul. Pharmacologie et toxicologie vétérinaires. In: Bulletin de l'Académie Vétérinaire de France tome 137 n°1, 1984. p. 93.
Effects of specific dopaminergic agonists and antagonists in the open-field test.
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Redox regulation of nitrosyl-hemoglobin in human erythrocytes.
Oxidative stress perturbs vascular homeostasis leading to endothelial dysfunction and cardiovascular diseases. Vascular reactive oxygen species (ROS) reduce nitric oxide (NO) bioactivity, a hallmark of cardiovascular and metabolic diseases. We measured steady-state vascular NO levels through the qua...
Stimulant effects of ethanol in adolescent Swiss mice: development of sensitization and consequences in adulthood
The initial representation of individual faces in the right occipito-temporal cortex is holistic : electrophysiological evidence from the composite face illusion
Identifying a facial feature (e.g. the eyes) is influenced by the position and identity of other features (e.g. the mouth) of the face, supporting the view that an individual face is represented as a whole in the human brain. To clarify how early in the time-course of face processing this holistic i...
Effectiveness and short-term tolerance of lurasidone in the management of schizophrenia
The functionally defined right occipital and fusiform "face areas" discriminate novel from visually familiar faces
Neuroimaging (PET and fMRI) studies have identified a set of brain areas responding more to faces than to other object categories in the visual extrastriate cortex of humans. This network includes the middle lateral fusiform gyrus (the fusiform face area, or FFA) as well as the inferior occipital gy...
Indicators of influenza and pneumococcal vaccination in French nursing home residents in 2011
Introduction: Older adults living in nursing homes (NH) are at high risk of developing influenza and pneumococcal infections. The objectives of this study were to describe vaccination coverage for influenza and pneumococcal among French NH residents and to investigate which NH structure- and organis...
Pharmacological study of the ASIC channels by animal toxins
The Acid-Sensing Ion Channels (ASIC) are widely expressed in the central and peripheral nervous system and are activated by extracellular acidification. They are involved in increasing number of physiological or pathological functions such as synaptic transmission, synaptic plasticity, learning, mem...
Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats
Parkinson's disease: A risk factor for osteoporosis
Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/c and IL-4R alpha knockout mice
International audience Antigen-induced bronchopulmonary hyper-reactivity (BHR) is generally associated with eosinophilia. It involves cytokines produced by Th2 lymphocytes, including IL-4, IL-5 and IL-13, which are implicated in IgE production, eosinophil differentiation and attraction, and related...
Medicated treatment in women transplanted with a pregnancy project: on two cases of lung and cardio-pulmonary transplantation
The industrialisation of hedonism. New body cults: from self-production to addictive perfectibility
`titrebThe industrialization of hedonism. New worshipping of the body: from production of oneself to addictive perfectibility`/titrebThe 21st century confirms a revolution: for a few decades, the perfectibility of the body has been concretized by unprecedented medical and technical progress. Life ex...
Rationality and rationalisation
Modulation of nociceptive transmission by group I metabotropic glutamatergic receptors and L-type calcium channels in the spinal cord : electrophysiological approach in vivo
Pain is an unpleasant experience which is part of our lives. When it does not last long time, it is often a warning sign for our organism. However unfortunately, in some pathological cases, it can last a long time, and become chronic, intolerable, and requires a treatment that is not always enough t...
Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode.
A blind volunteer with retinitis pigmentosa was chronically implanted with a self-sizing spiral cuff electrode around an optic nerve. Electrical stimuli applied to the nerve produced localized visual sensations that were broadly distributed throughout the visual field and could be varied by changing...
Development of the Alcohol Quality of Life Scale (AQoLS): a new patient-reported outcome measure to assess health-related quality of life in alcohol use disorder
Heteromerization of two pore domain potassium channels
Potassium channels are highly conserved among organisms, from plants to humans, where they are involved in several functions. Among them, the two pore domain potassium channels or K2P channels are dimers that produce background channels to control membrane resting potential and thus cell excitabilit...
Scientific Committee Opinion in response to the HCB referral — dossier BE-2015-1251. Paris, 18 December 2015
Le Haut Conseil des biotechnologies (HCB) a été saisi le 7 octobre 2015 par les autorités compétentes françaises (le ministère de l’Agriculture, de l’Agroalimentaire et de la Forêt) d’une demande d’avis relative au dossier EFSA-GMO-BE-2015-125 de demande d’autorisation de mise sur le marché du maïs...
Collateral effects of COVID-19 or forgotten from the crisis
In this period of pandemic, as in humanitarian disasters and during periods of confinement, people suffering from chronic diseases (diabetes, pulmonary diseases, hypertension, psychic diseases, renal insufficiency, situations of handicap…) or oncological diseases pay a heavy price, because they beco...
Effectiveness of drugs acting on adrenergic receptors in the treatment for tobacco or alcohol use disorders: systematic review and meta‐analysis
International audience Aim: To assess the efficacy of drugs directly acting on alpha- and beta-adrenergic receptors in the treatment of patients suffering from tobacco or alcohol use disorder.Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, studi...