Query : Substantia Nigra
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Oxidative stress and neuronal aging in Drosophila models of Parkinson disease : protective effects of mitochondrial uncoupling and autophagy-mediated chaperones proteins
Parkinson's disease (PD) is characterized by progressive motor disorders resulting in dopaminergic neurons degeneration in the substantia nigra. In this pathology, aging is a major predisposing factor. During my thesis, I examined initially, in vivo models used in the laboratory to study the PD in D...
Alterations in dopamine system and in its connectivity with serotonin in a rat model of Alzheimer’s disease
International audience Abstract Dopamine pathways alterations are reported in Alzheimer’s disease. However, it is difficult in humans to establish when these deficits appear and their impact in the course of Alzheimer’s disease. In the TgF344-Alzheimer’s disease rat model at the age of 6 months, we...
Development and Application of Quantitative Gradient-Echo MRI Techniques for Assessment of Iron and Myelin in the Multiple Sclerosis Brain
Degree: Doctor of Philosophy Abstract: Multiple Sclerosis (MS) is a progressive autoimmune and neurodegenerative disease of the Central Nervous System that results in demyelination and neuronal/axonal loss. Along with clinical evaluation, Magnetic Resonance Imaging (MRI) is the gold standard modalit...
Neuron-astrocyte interaction within the substantia nigra pars reticulata
Basal ganglia, a set of interconnected nuclei, are implicated in the elaboration, control and memorization of cognitive-motor behaviors. One of the main output structure of this network, the substantia nigra pars reticulata (SNr), integrates and conveys neuronal information to cortical areas via a t...
Study of molecular and cellular mechanisms involved in tne neuroprotective effects of Octadecaneuropeptide (ODN) in a murine model of Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a progressive loss of loss of dopaminergic (DA) neurons within the substantia nigra pars compacta (SNpc). Different mechanisms are associated with the neuropathogenesis of PD including dysfunction of the mitochondrial respirat...
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D5 dopaminergic receptors of the sub-thalamic core: involvement in the physiopathology of Parkinson’s disease
Burst-firing in the subthalamic nucleus (STN) is a hallmark of Parkinson’s disease. Previous in vitro studies have raised the hypothesis of the involvement of dopamine D5 receptor (D5R) in the genesis of this pathological activity. Here we have shown that D5R exert a constitutive activity in vivo, w...
Stereological investigation of serotonin type 3 receptors in the substantia nigra and dorsal raphe nucleus in the rat
Multiparametric MRI approach for the brainstem
Connecting the brain to the spinal cord, the brain stem Brainstem (BST) is an area of convergence of motor and sensory pathways. It has different nuclei, responsible for various functions such as motor skills, regulation of respiratory and cardiac rhythms, the origin of cranial nerves. Despite its i...
Improved segmentation of deep brain grey matter structures using magnetization transfer (MT) parameter maps.
Basal ganglia and brain stem nuclei are involved in the pathophysiology of various neurological and neuropsychiatric disorders. Currently available structural T1-weighted (T1w) magnetic resonance images do not provide sufficient contrast for reliable automated segmentation of various subcortical gre...
Role of the plasma membrane monoamine transporter (PMAT) in the central nervous system
High-affinity reuptake transporters exert a crucial role in the control of synaptic transmissionby ensuring the recycling of the released transmitters into the presynaptic terminals. Other typesof transporters such as Organic Cation Transporters (OCTs) and the Plasma MembranemonoAmine Transporter (P...
Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs
Somatostatin receptor subtypes were labeled with the somatostatin analogs [125I]CGP 23996 and [125I]MK 678 and the distribution of these receptors in rat brain was investigated using quantitative autoradiographic techniques. [125I]CGP 23996 and [125I]MK 678 specifically label different populations o...
Multiple System Atrophy : modelling and experimental strategy research
Abstract: Multiple system atrophy (MSA) is a rapidly progressing orphan disease characterized by neurodegeneration in several brain regions, including olivopontocerebellar and striatonigral systems, together with several brainstem autonomic nuclei. The hallmark of MSA is the presence of oligodendrog...
Inflammation: Role in Parkinson's Disease and Target for Therapy
Evidence is now overwhelming that inflammation is a central process in the pathogenesis of progressive Parkinson's disease (PD). The hallmark of this neuroinflammation is the activation of microglial cells and the secondary role of adaptive immunity in both the familial and idiopathic forms of PD, l...
Anatomical and Functional Study of the Serotonin2C Receptors Controls in the Basal Ganglia
This work of integrative neurobiology focuses on the study of the controls exerted by the 5-HT2C receptors in the basal ganglia, a group of subcortical structures involved in the control of motor behavior. 5-HT2C receptors exert three modalities of control over cells of the basal ganglia, including...
MRI Morphometry of the Brain and Neurological Diseases
The diagnosis of diseases of the brain is based on additional methods, confirming the clinical diagnosis. One of the most objective methods is magnetic resonance imaging (MRI). A detailed quantitative evaluation became possible after the introduction of MRI voxel‐morphometry–statistical analysis of...
Role of retinoic acid signaling in the development and functions of the nigrostriatal dopaminergic system
Retinoic acid (RA), the bioactive derivatives of vitamin A, is well known for its critical role in development and homeostasis of the nervous system. RA signaling depends on activities of RA-producing enzymes, such as retinaldehyde dehydrogenases (Raldh1, 2, and 3) and two classes of retinoid recept...
Adaptive plasticity of neuronal microcircuit of the base ganglia in Parkinson’s disease
The basal ganglia are a set of subcortical structures involved in psychomotor behaviour. Parkinson’s disease is the most common neurodegenerative disorder affecting the basal ganglia. The slow and progressive degeneration of dopamine (DA) neurons located in the substantia nigra pars compacta leads t...
Dopaminergic control of motor function in the cortex and the striatum
Primary motor cortex and striatum are involved in movement planification and selection. Dopamine regulates the neuronal activity of these two structures. The motor impairments observed in Parkinson's disease originates from the loss of dopamine neurons projecting from the substantia nigra pars compa...
Pharmacocorrection of mitochondrial dysfunction and energy imbalance of substantia nigra neurons in experimental Parkinson's disease in rats
Parkinson's disease (PD) is a progressive disease and the incidence increases markedly with age, treatment has significantly improved the quality of life of patients with PD, but statistics show that these patients continue to show shorter life expectancies compared to the general population. Aim of...
Parkinson's Disease Cell Vulnerability and Disease Progression
Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of P...
Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF
Local delivery of therapeutic molecules represents one of the limiting factors for the treatment of neurodegenerative disorders. In vivo gene transfer using viral vectors constitutes a powerful strategy to overcome this limitation. The aim of the present study was to validate the lentiviral vector a...
Opposite effects of group III metabotropic glutamate receptors activation in the globus pallidus or the substantia nigra pars reticulata in regulating motor control in Parkinsonian rats.
Ketamine modulation of the temporal pattern of discharges and spike train interactions in the rat substantia nigra pars reticulata.
One-dimensional migration of olfactory ensheathing cells on synthetic materials: Experimental and numerical characterization
Characterizing the mode of action of super long-acting beta2-adrenergic receptor agonists: A more effective therapeutic for Parkinson's disease.
Degree: Master of Science Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the Substantia nigra (SN) resulting in hypokinetic motor movements. The long-acting beta2-adrenergic receptor (β2-AR) agonist salmeterol has been shown to b...