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Differences in unemployment between males and females in France
The thesis provides a novel analysis of the differences in unemployment between males and females, taking into account, in addition to the rate, other important aspects of unemployment that have welfare implications for both individuals and the society where they live. It consists of three contribut...
Modeling In Vitro & In Vivo Radiotherapy Resistance in Diffuse Intrinsic Pontine Gliomas (DIPG)
Diffuse intrinsic pontine gliomas (DIPG) are the most severe pediatric brain tumours. Though accepted as the main therapeutic, radiotherapy is only transiently efficient and not even in every patient. We previously identified a heterogeneous response to radiotherapy at diagnosis (Castel et al., 2015...
Association between serum concentrations of perfluoroalkyl substances (PFAS) and expression of serum microRNAs in a cohort highly exposed to PFAS from drinking water
Background: Perfluoroalkyl substances (PFAS) are widespread synthetic substances with various adverse health effects. Not much is known about the modes of action of PFAS toxicity, but one likely mechanism is alteration of microRNA expression. Objectives: To investigate whether PFAS exposure is assoc...
Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study
Background: Concerns have been raised that synthetic oxytocin, a widely used obstetric tool for labor induction and augmentation, may have deleterious effects on the neuropsychological development of children. Few studies have examined the relationship between oxytocin-stimulated labor and emotional...
Synthetic Cannabinoid-Induced Psychoses In Hospitalized Patients : Clinical Characteristics And Patient Profile
Objective: As the classification of synthetic cannabinoid (SC)-induced psychoses is still a controversial issue, this study aimed to evaluate SC-induced psychoses in terms of patient profile and clinical characteristics with reference to their follow-up.Methods: A total of 46 male patients (n=46; me...
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Analysis of the distribution of wage income in Uruguay using synthetic cohorts
Resumen: El presente trabajo analiza la evolución de la distribución salarial en Uruguay por generaciones. Utilizando cortes transversales repetidos se estudió la desigualdad de ingresos para los individuos nacidos entre 1924 y 1991 y se vinculó con variables relevantes en la teoría del capital huma...
Long term morbidity of children treated with synthetic growth hormone
The literature is scarce regarding the long term effect of synthetic growth hormone (GH) treatment. The objective of this thesis was to analyse the morbidity of 6874 patients from the French SAGhE study treated by GH for short stature, focusing on three themes: Neurovascular risk: Using two populati...
Neurobiological origin of spurious brain morphological changes: A quantitative MRI study.
The high gray-white matter contrast and spatial resolution provided by T1-weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1-weighted images is predominantly driven by T1, other MRI para...
The measurement of unemployment using completed durations: evidence on the gender gap in unemployment in France
Magnetic resonance images integration methods in Monte Carlo dose calculations applied to stereotactic radiosurgery
In the context of quality assurance of radiotherapy treatment , magnetic resonance imaging (MRI)-only treatment planning removes contour uncertainties originating from image registration between MRI and computed tomography (CT). The main aim of the thesis is to develop methods to generate synthetic...
The Duration-Based Measurement of Unemployment: Estimation Issues and an Application to Male-Female Unemployment Differences in France
This paper examines how unemployment can be measured in normative fashion - taking into account the mean and inequality of spell lengths - and how the extent of unemployment can be estimated from cross section data of the type found in labour force surveys. The issue is not straightforward since in...
Data from: Comparing radiomic classifiers and classifier ensembles for detection of peripheral zone prostate tumors on T2-weighted MRI: a multi-site study
Background: For most computer-aided diagnosis (CAD) problems involving prostate cancer detection via medical imaging data, the choice of classifier has been largely ad hoc, or been motivated by classifier comparison studies that have involved larger synthetic datasets. More significantly, it is curr...
A Novel Sparse Group Gaussian Graphical Model for Functional Connectivity Estimation
International audience The estimation of intra-subject functional connectivity is greatly complicated by the small sample size and complex noise structure in functional magnetic resonance imaging (fMRI) data. Pooling samples across subjects improves the conditioning of the estimation, but loses subj...
Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya
We have recently described 95 predicted alpha-helical coiled-coil peptides derived from putative Plasmodium falciparum erythrocytic stage proteins. Seventy peptides recognized with the highest level of prevalence by sera from three endemic areas were selected for further studies. In this study, we s...
Intergenerational economic mobility in Mexico
Abstract: This article documents several measures of intergenerational economic mobility in Mexico. We employ census data available for 1990 to 2015 on earnings. Since censuses do not link individuals over time, the empirical strategy follows a synthetic approach by matching individuals with synthet...
Loss-Of-Function Mutations In The Trace Amine-Associated Receptor 1 (TAAR1) Among Patients With Major Mental Disorders
Objectives. To identify and functionally characterize variants in the trace amine associated receptor 1 (TAAR1) in a cohort of patients suffering from major mental disorders.Background and aims. The G protein-coupled receptor (GPCR) TAAR1 is widely expressed across brain areas involved in emotions,...
Symptoms, respiratory function and bronchial inflammation related to chronic occupational exposure to whole oil mists: feasibility study
Les fluides de coupe sont largement utilisés dans les industries mécaniques des machines-outils pour assurer la lubrification et le refroidissement des pièces métalliques. Lors de l'usinage, les machines-outils provoquent, de par leur grande vitesse de rotation, l'émission d'huile. On estime qu'envi...
Fertility in Finland in the 1980s and 1990s: Analysis of Fertility Trend by Age and ParityAge and ParityFertility in Finland in the 1980s and 1990s: Analysis of Fertility Trend byAge and ParityFamilial, Situational, and Attitudinal Determinants of Third-Birth Intentions and Their Uncertainty
The purpose of this article is to describe the fertility trend in Finland from 1982 to 1999 by age and parity, using age- and parity-specific birth intensities and synthetic cohort measures of period fertility. The findings are discussed in the light of the concurrent changes in family policy and ma...
The Impact of the First World War on the State and Structure of the Cracow Population. Research Based on Demographic Variant Projections
The article assesses the effects of the First World War on the population of Cracow, visible in the state and structure of the town’s population. The collected statistical materials (mainly the publications of the City’s Statistical Office) have been used to carry out an annual projection of the siz...
Child physical development in the UK: the imprint of time and socioeconomic status
International audience ObjectivesSocial health inequalities remain a key policy challenge. The existing literature has not presented a synthetic view on the evolution of inequalities in physical development across childhood. We examine social disparities as children grow older using a range of diffe...
Savings and social security for households in Mexico: an analysis of synthetic cohorts
En esta investigación se revisan los perfiles etarios del ahorro corriente de los hogares en México según condición de acceso a servicios médicos por parte del trabajo. El estudio se basa en un análisis de cohortes sintéticas que permite analizar el comportamiento del ahorro corriente a lo largo del...
Use of biphase ceramics in severe acetabular bone losses in total hip prosthesis (PTH) replacements: study of 22 cases with long-term follow-up
Management of bone loss in revision total hip replacement remains a challenge. To eliminate any immunological or infectious problem and so to try to improve the long-term results obtained with allografts, the authors used synthetic ceramics as bone substitutes since 1995. We reviewed 13 of the patie...
Association of phthalate exposure with autistic traits in children
Background: Phthalates are synthetic chemicals with endocrine-disrupting properties. They are reportedly associated with various neurotoxic outcomes. Studies on exposure to phthalates and children’s autistic traits have shown inconsistent results with respect to sex and susceptible time periods. We...
Global DNA methylation mediates the association between serum perfluorooctane sulfonate and carotid intima-media thickness in young and middle-aged Taiwanese populations
Purpose: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals used in the manufacture of many everyday products. Previous reports have shown PFAS exposure may contribute to cardiovascular diseases (CVD). Recent studies have also identified a critical role for DNA m...
Association between triclosan exposure and obesity measures among 7-year-old children in northern China
Background: Triclosan (TCS) is a widely used synthetic antibacterial compound with ubiquitous human exposure. Animal studies have suggested the obesogenic effect of TCS exposure, but knowledge regarding its impacts on childhood obesity was limited. Objective: To investigate the associations of TCS e...