Query : Thérapie cellulaire
- Environmental studies193
- Methods and Statistics61
- Communication Sciences30
- Musicology and Performing Arts6
- Art and Art History4
- Political Science4
- Social Anthropology and Ethnology2
- Archaeology and Prehistory2
- Architecture and Space Management2
- Classical Studies2
- History, Philosophy and Sociology of Sciences2
- Blog Post2
- boris demain2
- chantal bauchetet2
- christine preaubert-sicaud2
- dominique jaulmes2
- olivier detante2
- oriane rabesandratana2
- p vogt2
- romain fol2
- virginie tournay2
- virginie tournay2
- a mathur1
- a orcurto1
- abderrahim el guerrab1
- abhishek kumar1
- adeline berger1
- adrian duval1
- adrien acquistapace1
- adrien engel1
- adrien grassin1
- adrien laroche1
Conditions of Access
- Open Access257
- Restricted Access or Use105
- All Rights Reserved10
- Free Access6
- Creative Commons5
- No available data for your search terms.
Lipid rafts of platelet membrane as therapeutic target : role of "Omics"
Latelets are blood ce lis at the crossroads of both haemostasis and thrombosis. The majority of platelet functions depend on their membrane, which contains numerous, ordered lipid microdomains named lipid rafts. These microdomains play a pivotai role in all phases of plateletmediated haemostasis. Li...
EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry
Hepatitis C is a major global health burden with 160 million infected individuals worldwide. This long-term disease, caused by a small positive-strand ribonucleic acid (RNA) enveloped virus, namely hepatitis C virus (HCV) evolves slowly. Nowadays, no vaccine is available and current treatments are u...
Control of the genetic expression of tissue factor and angiogenesis by Hypb, H3K36 methyltransferase Regulation of the genetic expression of tissue factor and angiogenesis by Hypb, H3K36 methyltransferase
The thesis described, in the first chapter, an opposite regulatory effects of PI3K/Akt pathway and Erk1/2 pathway on tissue factor(TF) gene expression in vitro. TF is a keymolecule required to initiate blood coagulation, and is now accepted to be essential forembryo development, maintenance of vascu...
Cell therapy in cardiology: review of first randomised clinical trials (Cell therapies in cardiology: results from the first randomised clinical trials]
Following acute myocardial infarction, necrotic cardiac tissue is replaced by scar leading to ventricular remodeling and pump failure. Transplantation of autologous bone marrow-derived cells into the heart, early post-infarct, aims to prevent ventricular remodeling. This strategy has been evaluated...
Development of a pathophysiological model of foamy macrophages of atherosclerosis : phenotypic and functional characterization and selection of specific human antibodies
Atherosclerosis is a chronic inflammation linked to the retention of oxidized LDL on the surface of the arterial wall leading to the formation of so-called "atherosclerotic" plaques prone to rupture and to further cardiovascular events (stroke, heart attack, pulmonary embolism). Macrophages infiltra...
Look at these search results from a different perspective
Therapeutic effects of TGT-β induced regulatory T cells on the established autoimmune and inflammatory diseases
Recent studies revealed that nTregs has less therapeutic effects on established autoimmune diseases. Current study asks if iTregs induced ex-vivo with TGF- can treat the established autoimmune diseases. In allergic asthma we observed that adoptive transfer of iTreg significantly suppressed airway an...
New format of human recombinant antibody libraries for functional screening at large scale
Since 2000, monoclonal antibodies (mAb) have become essential and routine drugs in therapy and particularly in oncology. The field continues to grow very quickly and given the abundance of molecules available, it is increasingly important to bring innovative molecules with a high added value for the...
Mitochondria transfer from mesenchymal stem cells to glioblastoma stem cells : effects on metabolism and chemotherapy resistance
Glioblastomas are heterogeneous tumors with high metabolic plasticity. Their poor prognosisis linked to glioblastoma stem cells (GSCs) which provide resistance to therapy, in particularto temozolomide (TMZ). It is worsened with mesenchymal stem cells (MSCs) recruitment. Weshow that, following tunnel...
Molecular study of melanoma chemoresistance to vinca-alkaloids and MAP Kinase inhibitors
Malignant melanoma (MM), one of the most intrinsically resistant cancers to anticancer agents and presenting a strong ability to develop acquired resistance, remains a therapeutic challenge. A better understanding of the mechanisms involved in MM chemoresistance should provide therapeutic targets or...
Olfactory ecto-mesenchymal stem cells in regenerative medicine : therapeutic potential from bench to bedside
The lack of effective treatments to regenerate the brain led research into a new field: the cellular therapy. In this context, stem cells appear as a tool of choice to regenerate brain tissues and restore cognitive abilities. Olfactory ecto-mesenchymal stem cells (OE-MSCs), located in the nasal cavi...
Therapeutic potential of mesenchymal stromal cells in recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by loss-of-function mutations in COL7A1 encoding type VII collagen. Type VII collagen forms anchoring fibrils which are essential structures for dermal-epidermal adherence. Patients with RDEB suffer since birth from sk...
In vitro and in vivo study of the neuroprotective effect of a selenoprotein T-derived peptide, PSELT, in a model of Parkinson disease
Les maladies neurodégénératives telles que la maladie d'Alzheimer, la maladie de Parkinson et la maladie de Huntington sont des pathologies progressives qui affectent le système nerveux, conduisant à la mort de certaines cellules nerveuses. Toutes ces maladies se caractérisent par la perte progressi...
Design, synthesis and characterization of vectors for nanomedicine : applications in anti-cancer therapy
Cancer research is now taking advantage of nanomedicine that is to say the use of nanoparticles to increase treatment efficiency and reduce toxicity. In this context, this work has been devoted to the design and synthesis of nano objects for applications in cancer therapy. These systems are based on...
Biochemical and cellular characterization of the interplay between glutamine metabolism, mTOR and Notch1 signaling in cancer therapy
Tumorigenesis is a multistep process, consisting of genetic alterations that drive the malignant transformation of normal human cells. During this transformation, different oncogenic pathways are upregulated. mTORC1 and Notch1 signaling are well-known oncogenic pathways which play a central role in...
Tissue Factor and Endothelial colony forming cells : phenotypical aspects in inflammatory conditions
Endothelial colony-forming cells (ECFCs) can be obtained from human bone marrowCD34+ cells. In spite of the essential role of the tissue factor (TF) in coagulation triggeringand angiogenesis, its expression during endothelial differentiation is not established. We showthat CD34+ cells express TF, bu...
Identification of the transcription factor HOXA9 as a therapeutic target in renal cell carcinoma and targeting with DNA ligands
Kidney cancer accounts for 3% of adult cancers. It is a heterogeneous and insidiousdisease with a good prognosis when it is discovered early. Unfortunately, 5-year survivalremains below 10% when it is diagnosed at metastatic stages. Treatment is based onsurgery for localized tumors and on the use of...
Application of the immunolocalization for researching the human corneal endothelial stem cells
The control of corneal transparency depends on the integrity of the mono-stratified corneal endothelium, which is considered devoid of regenerative capacity after birth in humans. In pathological conditions leading to blindness by irreversible corneal edema, the significant losses of endothelial cel...
Blocking the signalling of myostatin and other ligands of the TGF-β superfamily increases the success of myoblast grafting in dystrophic mice
La dystrophic musculaire de Duchenne est la plus sévère des dystrophies musculaires de l'enfant. De transmission récessive liée à l'X, elle touche 1 nouveau-né masculin sur 3500. L'absence presque complète de la dystrophine, protéine sub-sarcolémique, est le premier marqueur moléculaire de cette myo...
cardiomyocyte nuclear reprogramming toward a progenitor state after partial cell fusion with adult stem cell
Regenerative cell therapy offers potential applications in many diseases involving cell loss. However, following myocardial infarction and the dramatic decrease in the number of cardiomyocytes, the injection of stem cells led to a poor and transient improvement of cardiac function. Therefore stem ce...
Effect of Melatonin on the Risk of Osteoporosis, Brain Energy Metabolism and Remyelination in an Experimental EAE Mouse Model
Multiple Sclerosis (MS) is a chronic auto-immune demyelinating and neurodegenerative disease of the CNS. It represents the leading cause of non-traumatic disability in young adults and especially women. Despite all the efforts of researchers, the exact cause of MS remains unknown to this day. Accord...
When regulating and standardising one another: Quality control of human cell products: towards a factory of cell therapies
The paper aims to show the co-construction of a normalised medical process known as «cell therapy » and legal standards of quality control relating to the medical preparation of human cells. The necessity of an administrative policy for these products directly results from bioethics controversies. B...
Novel mechanisms in tolerogenic dendritic cells
The research focused on tolerogenic dendritic cells during the last 20 years has culminated on their therapeutic application in several clinical trials. Among these trials, our team is currently conducting the first trial in the context of kidney transplantation using tolerogenic dendritic cells gen...
Acute pulmonary inflammation in intensive care unit : research development in diagnosis, prevention and immunomodulatory therapies
Pneumonia and acute respiratory distress syndrome (ARDS) are two facets of severe acute lunginflammation, often met in intensive care unit (ICU). Rapid diagnosis of pneumonia remains essential inorder to optimize their management. We worked on setting up a quick test diagnosis based on theintensity...
The prion-like properties of the mutant huntingtin protein : demonstration in in vitro and in vivo systems
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that affects approximately 3 - 8 people in 100,000 individuals worldwide. HD is caused by a mutation in the HTT gene, which codes for the protein huntingtin (HTT), consisting of an expansion of 35 CAG repeats in the exon 1...
Tumor growth modeling treated by radiotherapy
In this thesis, we have proposed a Markov chain modeling of the cell and tumor behaviors during radiotherapy. Our approach is based on the target theory where it is assumed that the cell contains a number of sensitive sites called targets which must be all deactivated to produce the cell death. A fi...