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Transmissibility of Alzheimer pathology in a non-human primate Transmissibility of Alzheimer pathology in a non-human primate: 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PD), 18-22 Mars 2015, Nice, (France)
Contrasted perceptions of Alzheimer's disease in the media and in the cultural productions: changes from 2010 to 2018
Cognitive changes under memantine according to vitamin D status in Alzheimer patients : an exposed/unexposed cohort pilot study
International audience Memantine is a symptomatic treatment that partially prevents cognitive decline in Alzheimer disease (AD). The neuroprotective effects of memantine and vitamin D may potentiate each other, with benefits for cognition. The objective of this exposed/unexposed pilot study was to d...
Development of fluorescent biosensors and inhibitors to probe and target CDK5/p25 in glioblastoma
CDK5 is a protein kinase ubiquitously expressed but mainly activated in the central nervous system, where it plays an important role in neuronal functions such as synaptic transmission, axonal guidance and migration, synaptic plasticity and neuronal development. CDK5 is associated with p35 protein a...
Multidisciplinary analysis of biological effects of novel analogs of the neurosteroid allopregnanolone : evidence for a proliferative, neurogenic and neuroprotective action
This PhD work allowed us to successfully characterize structural analogs of allopregnanolone. Some of these analogs showed beneficial effects and advantages with respect to the molecule of reference. In particular, the analog O-allyl-AP stimulates proliferation of progenitor cells in different neura...
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Transcranial Ultrasound Holograms for the Blood-Brain Barrier Opening
[EN] Treatments for neurological diseases are strongly limited by the inefficient penetration of therapeutic drugs into the diseased brain due to the blood-brain barrier (BBB), and therefore no health improvement can be achieved. In fact, the BBB is a protection mechanism of the human body to avoid...
Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.
The role of autophagy and its relationship with apoptosis in Alzheimer disease (AD) pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely digested substrates, amyloid-β (Aβ) peptide accumulation in vacuoles and cell death. Aβ, in turn, has been found to affect a...
Effects of the Alzheimer's disease-associated Amyloid-β peptide on the DNA repair systems
Alzheimer's disease (AD) is an age-related neurodegenerative disorder which leads to a progressive and irreversible loss of cognitive and behavioral functions. Two major pathological hallmarks are affecting patients with AD: intracellular neurofibrillary tangles (mostly constituted of the hyperphosp...
Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?
International audience BACKGROUND: Alzheimer's disease has become a growing socio-economical concern in developing countries where increased life expectancy is leading to large aged populations. While curing Alzheimer's disease or stopping its progression does not appear within reach in a foreseeabl...
Módulo de etiquetado de espacio y tiempo de EIMER APP, aplicación de realidad aumentada orientada a ayudar a personas con alzhéimer
The present project consists of the execution of an app module destined to people who suffer Alzheimer’s disease, helping them to remember and to overcome obstacles in daily life. The main motivations of this project have been the desire of giving it a social approach for helping people and the curi...
Consensus 2012 sur le diagnostic et le traitement des patients atteints de démence en Suisse [Consensus 2012--diagnosis and treatment of patients with dementia in Switzerland].
The 2012 Swiss consensus paper on diagnosis and management of patients suffering from dementia resulted from the work of an expert panel who met on March 23d to 25th in Luzem. Based on a literature review, panel members wrote a first draft that was subsequently circulated among multiple dementia exp...
The misuse of psychoactive substances in general medicine
The high level of psychotropic drugs consumption in France, the extent of the medical and societal challenges of neurological and psychiatric diseases, and population projections in terms of aging, emphasize the importance of mobilizing health care stakeholders. The French healthcare system is also...
Effects of ω-3 fatty acids on cerebro-vascular inflammation associated with Alzheimer disease and cerebral amyloid angiopathies
Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) are characterized by Amyloid β-peptides depositions in the brain and cerebral vasculature respectively. Because DHA-diet is associated with a reduced risk of AD, the main objective of my thesis was to evaluate the impact of a DHA-diet on...
PRESSE: Article dans le magasine mensuel "Le 15ème Jour" de l'ULg - "In Memoriam – Alzheimer, une pathologie complexe étudiée au service de neuropsychologie"
Potential role of herpes simplex virus type 1 in Alzheimer’s disease
The origin of the sporadic form of the Alzheimer's disease (AD) remains still widely unknown. However, an adequacy between environmental and genetic factors is highly probable. Numerous arguments suggest that the virus herpes simplex of type 1 (HSV1) by infecting and replicating in the central nervo...
Cerebral small vessel disease genomics and its implications across the lifespan
International audience Cerebral small vessel disease genomics and its implications across the lifespan Muralidharan Sargurupremraj et al. # White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk fac...
Un jardin comme outil de soins en unité cognitivo-comportementale
National audience Les unités cognitivo-comportementales (UCC) sont des unités spécialisées au sein des services de soins de suite et de réadaptation (SSR) destinées aux personnes atteintes de la maladie d’Alzheimer. Ces unités ont été créées en écho à la mesure numéro 17 du IIIe Plan Alzheimer. Pour...
Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease
International audience Alzheimer's disease (AD) is the main cause of dementia and a major health issue worldwide. The complexity of the pathology continues to challenge its comprehension and the implementation of effective treatments. In the last decade, a number of possible targets of intervention...
Design, synthesis and evaluation of compounds interacting with protein degradation for the treatment of neurodegenerative diseases
Two physiopathological processes are involved in Alzheimer’s disease: the senile plaques (amyloid pathology) consisting of Aβ peptide aggregates and neurofibrillary tangles (Tau pathology) caused by the accumulation of hyper and abnormal phosphorylated Tau protein. Currently, only symptomatic treatm...
Donepezil increases contrast sensitivity for the detection of objects in scenes
We assessed the effects of donepezil, a drug that stimulates cholinergic transmission, and scopolamine, an antagonist of cholinergic transmission, on contrast sensitivity. 30 young male participants were tested under three treatment conditions: placebo, donepezil, and scopolamine in a random order....
Bioethics and the Patent Eligibility of Human Embryonic Stem Cells-Related Inventions in Europe (Edition 1)
The topic of this book is one of the most contentious, complex and at the same time very important in many respects. Latest achievements in the biotechnology industry related to the stem cell technology are quite important. On the one hand, human embryonic stem cells are viewed as strong tools to be...
Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease
International audience The frontal cortex is a brain structure that plays an important role in cognition and is known to be affected in Alzheimer's disease (AD) in humans. Over the past years, transgenic mouse models have been generated to recapitulate the main features of this disease, including co...
Multimodal MRI evaluation of cerebral modifications in prodromal Alzheimer's disease patients : optimization of T2* relaxometry by MRI
One of the main goals of modern neuroimaging is the identification of new markers that can help in the diagnosis and monitoring of neurological pathologies. Multimodal magnetic resonance imaging (MRIm), is an approach allowing the evaluation of several complementary biomarkers within one MRI. This a...
The need for a consensus in the use of assessment tools for Alzheimer's disease: The Feasibility Study (assessment tools for dementia in Alzheimer Centres across Europe), a European Alzheimer's Disease Consortium's (EADC) survey
Contributions to the mathematical and numerical modelling of biological problems : applications to Prions and Alzheimer's disease
The aim of this thesis is to study, under several aspects, the formation of amyloids from proteins polymerization. The mathematical modelling of these phenomena in the case of in vitro or in vivo polymerisation remains questioned. We then propose here several models, which are also investigated from...