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22q11 Deletion Syndrome and Urogenital Manifestations: A Clinicopathological Case Report.
Deletion in the chromosomal region 22q11 results from the abnormal development of the third and fourth pharyngeal pouches during embryonic life and presents an expansive phenotype with more than 180 clinical features described that involve every organ and system. A 23-year-old African woman presente...
Clinical prediction of deep venous thrombosis through two risk assessment methods in combination with rapid quantitative ELISA D-dimer testing among unselected patients.
Purpose The optimal approach to diagnosing deep venous thrombosis is not entirely clear. In this prospective cohort study, we aimed to evaluate the yield of two methods of assessing the pretest probability of deep venous thrombosis-the treating physician's implicit assessment and the Wells score, a...
Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment
Correlates of frailty, prediction of functional decline and preventative approaches - selected results from the lausanne cohort 65+ (lc65+) study (Switzerland) (Lausanne) and the longitudinal urban cohort ageing study (Lucas) (Germany)
Overall introduction.- Longitudinal studies have been designed to investigate prospectively, from their beginning, the pathway leading from health to frailty and to disability. Knowledge about determinants of healthy ageing and health behaviour (resources) as well as risks of functional decline is r...
Evaluation of plasticizer migration of the plasticizers from medical devices in polyvynilechloride (PVC) and developpement of a protection tool by sol gel technique
Plasticizers in medical devices (MD) made of flexible PVC, such as infusion sets of nutrition tubings, are able to migrate into infused solutions and so come in contact with the patient. DEHP (diethylhexylphtalate) was the main plasticizer used in these MD up until 2010. It has been shown to be repr...
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Future perspectives in melanoma research: meeting report from the "Melanoma Bridge";: Napoli, December 3rd-6th 2014.
The fourth "Melanoma Bridge Meeting" took place in Naples, December 3-6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers. Until recently systemic therapy for metastat...
Silicon particles as trojan horses for potential cancer therapy
Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1
Bringing Safe and Standardized Cell Therapies to Industrialized Processing for Burns and Wounds
Cultured primary progenitor cell types are worthy therapeutic candidates for regenerative medicine. Clinical translation, industrial transposition, and commercial implementation of products based on such cell sources are mainly hindered by economic or technical barriers and stringent regulatory requ...
Family perspectives on a proper medical treatment for people in prolonged vegetative and minimally conscious states
Whenever the legitimacy of a new or ethically contentious medical intervention is considered, a range of influences will determine whether the treatment becomes accepted as lawful medical treatment. The development and introduction of abortion, organ donation, gender reassignment, and non-therapeuti...
Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura
Because of the possible involvement of cytokines in gram-negative septicemia, we investigated serum levels of tumor necrosis factor alpha, interleukin-1 beta, alpha interferon, and gamma interferon in children with gram-negative sepsis and purpura fulminans. We studied 55 patients (ages, 1 month to...
On the Analogy between Field Experiments in Economics and Clinical Trials in Medicine
International audience Randomized experiments, as developed by Esther Duflo and Abhi-jit Banerjee at the Abdul Latif Jameel Poverty Action Lab (J-PAL), offer a novel, evidence-based approach to fighting poverty. This approach is original in that it imports the methodology of clinical trials for appl...
The Prevalence of Occupational Asthma and Rhinitis among Animal Laboratory Workers at Health Sciences Laboratory Animal Services (HSLAS), University of Alberta; A cross-sectional Study
Degree: Master of Science Abstract: Introduction: Laboratory animal allergy (LAA) is a recognised occupational health problem that can cause significant morbidity among exposed workers and imposes a burden on employers and industry. Since first described, many laboratories have introduced preventive...
Health care-associated native valve endocarditis: importance of non-nosocomial acquisition.
BACKGROUND: The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined. OBJECTIVE: To compare the characteristics and outcomes of community-associated and nosocomial and non-nosocomial health care-associated native valve en...
The Perceived Value of Passive Animal Health Surveillance: The Case of Highly Pathogenic Avian Influenza in Vietnam
International audience Economic evaluations are critical for the assessment of the efficiency and sustainability of animal health surveillance systems and the improvement of their efficiency. Methods identifying and quantifying costs and benefits incurred by public and private actors of passive surv...
Study on the P-wave feature time course as early predictors of paroxysmal atrial fibrillation
Clinical value of immunoscintigraphy in colorectal carcinoma patients: a prospective study.
Fifty-seven patients with suspected CEA-producing tumors were studied prospectively by radioimmunoscintigraphy (RIS) using a 123I-labeled anti-CEA monoclonal antibody (MAb) (essentially the F(ab')2 or Fab fragments) and emission computed tomography (ECT). Results of RIS were compared to those of a c...
Assessment of bimanual performance in 3-D movement analysis: Validation of a new clinical protocol in children with unilateral cerebral palsy
The "Be an Airplane Pilot" (BE-API) protocol is a novel 3-D movement analysis (3DMA) protocol assessing the bimanual performance of children during a game. This study aimed to investigate the reliability and validity of this protocol in children with unilateral cerebral palsy (uCP). Angular waveform...
GREATER TROCANTHERIC PAIN SYNDROME: CONSERVATIVE OR SURGICAL TREATMENT?
GREATER TROCANTHERIC PAIN SYNDROME: CONSERVATIVE OR SURGICAL TREATMENT?Joana silva1, Joana Matos1, u00darsula Martins1, Bruno Guimaru00e3es1, Inu00eas Tu00e1boas1, Eurico Monteiro21 Physical Medicine and Rehabilitation, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal2 Orthopaed...
Incident Reports From Anesthesia In Morbid Obesity According To PAAD Thai Study
Incident reports from anesthesia in morbid obesity according to PAAd Thai studyOraluxna Rodanant, M.D.* Waraporn Chau-in, M.D.** Somrat Charuluxananan, M.D.*Santhiti Morakul, M.D.*** Sukanya Pongruekdee, M.D.#, Umpawan Tanyong, M.D.##* Department of Anesthesiology, Faculty of Medicine, Chulalongkorn...
Delineating the biology of Anaplastic Lymphoma Kinase (ALK) and its resistance to crizotinib
Degree: Doctor of Philosophy Abstract: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase receptor that was initially identified as a potent oncogenic driver in anaplastic large-cell lymphoma (ALCL) in the form of NPM-ALK fusion protein. Various forms of oncogenic ALK proteins have been...
The Effect Of Use Complementary And Alternative Medication Combined Conventional Medicine In Chronic Pain Patients
Background: In recent years, there has been a remarkable increase in interest and use of complementary and alternative medicine (CAM). Patients with chronic pain commonly experience depression, sleep disturbance,fatigue, and decreased overall physical and mental functioning.Purpose:1. The situation...
Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey.
The optimal hemoglobin (Hb) threshold at which to initiate red blood cell (RBC) transfusion in patients with acute brain injury is unknown. The aim of this survey was to investigate RBC transfusion practices used with these patients. We conducted a web-based survey within various societies of critic...
Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components
Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length.
We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. As part of the EPISONO cohort (São Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment...