Type 2 diabetes is now a real global public health problem. It results from a defect of mass and / or function of pancreatic beta cells. The identification and understanding of the mechanisms underlying these defects would help develop strategies to restore the functional beta cell mass. Glucocortic...

All humans are exposed to chemicals in everyday life, from food, indoor environment, cosmetics and other products that surround us at home and at work. Endocrine disruptors (EDCs) are man-made compounds that can bind to cell receptors and mimic or block the functions of natural hormones potentially...

Insulin secretion is a major physiological function triggered in the body upon glucose entry into pancreatic β cells. This process is naturally subject to modulation by numerous metabolites, neurotransmitters or hormones. Among the modulatory hormones, incretins, mainly Glucagon Like Peptide (GLP1),...

Dieta rica em probióticos ajuda na prevenção e tratamento de doenças, bem como no equilíbrio da microbiota intestinal. Esta é uma revisão bibliográfica que buscou avaliar o efeito dos probióticos na prevenção e tratamento de câncer e diabetes. As bases de dados eletrônicas foram: Scielo, LILACS, Bib...

Type 2 Diabetes is a major health care problem responsible for early morbidities and mortality. T2D prevalence inexorably increases due to dramatic changes in our way of life. T2D is preventable but no generally curable and present medications fail to prevent the worsening of glucose control and the...

Peroxisome proliferator-activated receptors γ2 and α are nuclear factors known to be important regulators of lipid and glucose metabolism. Two polymorphisms, namely PPARγ2 P12A and PPARα L162V, were investigated for their individual and interaction effects on glucose and insulin homeostasis. Genotyp...

Following many studies lead on the inhibition of glycogen phosphorylase (GP) in our laboratory an trough several collaborations, this thesis describes in five chapters and a detailed experimental section, the most recent advances in the areas of synthesis and biological evaluation of GP’s catalytic...

HNF1beta is a POU transcription factor that is frequently mutated in patients that suffer from diabetes and renal cystic dysplasia. This protein has the peculiar ability to bind mitotic chromosomes and behave as a gene bookmarking. Here we show that the capacity of HNF1beta to bind to DNA plays an e...

Sociology has been interested in chronic diseases for some 40 years and the number of works is increasing. The predominance of chronic diseases in Western countries can only be accentuated by the combination of an ageing population and therapeutic advances that transform previously rapidly fatal dis...

Summary Introduction: In high-income countries, socio-economic status is related to differences in the prevalence and incidence of cardiovascular risk factors. In middle-income countries such as Mexico, the evidence is lower, so the aim of the study was to estimate trends in the prevalence of six of...

Degree: Master of Science Abstract: Background: It is well known that exercise can improve glycemic control in individuals with type 2 diabetes (T2D). However, the glycemic response to exercise is highly variable. One of the primary causes of variability in response to a single bout of exercise may...

Neste trabalho será estudada a prevalência de obesidade entre dois grupos de gestantes com diabetes, separando entreaquelas que necessitam de terapêutica medicamentosa e as que conseguem bom controle com manejo não medicamentoso. O diabetes gestacional é a intolerância aos carboidratos diagnosticad...

International audience

Adenosine (ADO) has been implicated as a pathophysiological factor in contrast media (CM)-induced acute renal failure, which has been encountered more often in patients with diabetes and impaired renal function. Therefore, we studied the renal vascular response to exogenous and endogenous ADO in str...

Oxidative Stress in Diabetes Mellitus: Is There a Role for Hypoglycemic Drugs and/or Antioxidants?

OBJECTIVES: Capillary rarefaction is a hallmark of untreated hypertension. Recent data indicate that rarefaction may be reversed by antihypertensive treatment in nondiabetic hypertensive patients. Despite the frequent association of diabetes with hypertension, nothing is known on the capillary densi...

homocysteine is a potentially atherogenic molecule and is considered an independent risk factor for cardiovascular diseases. For patients with chronic kidney disease or generally with renal function reduced the level of homocysteine in serum is high. Uric acid is associated with an increased risk of...

Periodontitis and Diabetes Mellitus

BACKGROUND: As a consequence of the increase in life expectancy, hepatobiliary surgeons have to deal with an emerging aged population. We aimed to analyze the liver function and outcome after right hepatectomy (RH) in patients over 70 years of age. METHODS: From January 2006 to December 2009, we pro...

Le glucose est notre principale source d'énergie. Après un repas, le taux de glucose dans le sang (glycémie) augmente, ce qui entraine la sécrétion d'insuline. L'insuline est une hormone synthétisée au niveau du pancréas par des cellules dites bêta. Elle agit sur différents organes tels que les musc...

Antagonism of renin-angiotensin-aldosterone system is exerted through angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, renin inhibitors and mineralocorticoid receptor antagonists. These drugs have been successfully tested in numerous trials and in different clinical settin...

OBJECTIVES: To evaluate the prevalence and clinical presentation of myocardial infarction (MI) and myocarditis in young adults presenting with chest pain (CP) and an elevated serum troponin I (TnI) to the emergency department (ED). DESIGN: Retrospective, observational, single-centre study. PARTICIPA...

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is the most frequent form of primary liver cancer and chronic infection with hepatitis C virus is one of the main risk factors for HCC. This study analyses the characteristics of the patients with chronic hepatitis C participating in the Swiss Hepat...