Query : drug treatment
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Management of Resistance to First-Line Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitor Therapy.
A decade after the discovery of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (EML4-ALK) rearrangements in non-small cell lung cancer (NSCLC), several inhibitors have gained regulatory approval, and their sequential use has deferred platinum-based chemotherapy to...
Drug Abuse Treatment Outcome Study (DATOS), 1991-1994: [United States]
<p>Drug-Abuse Treatment Outcomes Study (DATOS) is a prospective study designed to determine the outcomes of adult drug abuse treatment delivered in typical, stable, community-based programs and to provide comprehensive information on continuing and new questions about the effectiveness of drug abuse...
Intermittent Preventive Treatment as a malaria control strategy in children
Malaria is one of the most common infectious diseases in the world and 40% of the world population is exposed to malaria. Despite the current control strategies such as rapid diagnosis and treatment of disease cases, use of insecticide impregnated materials and indoor residuals spraying with insecti...
Pharmacogenomic and High-Throughput Data Analysis to Overcome Triple Negative Breast Cancers Drug Resistance
Given the large number of treatment-resistant triple-negative breast cancers, it is essential to understand the mechanisms of resistance and to find new effective molecules. First, we analyze two large-scale pharmacogenomic datasets. We propose a novel classification based on transcriptomic profiles...
Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN.
Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic ther...
National Survey on Drug Use and Health: 4-Year R-DAS (2002 to 2005, 2006 to 2009, and 2010 to 2013)
This file includes data from the 2002 through 2013 National Survey on Drug Use and Health (NSDUH) survey. The only variables included in the data file are ones that were collected in a comparable manner across all four years from 2002-2005, from 2006-2009, or from 2010-2013. The National Survey on D...
Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.
Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has shown systemic and central nervous system (CNS) efficacy in the treatment of ALK-positive non-small-cell lung cancer (NSCLC). We investigated alectinib as compared with crizotinib in patients with previously untreated,...
Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies
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The complex SEA : structure and Function of a New Regulator of the Way TORC1
The TORC1 pathway plays a major role in controlling cell growth and response to various stresses. Deregulation of this pathway is found in many cancers and other diseases. In my thesis, I have shown that the SEA complex emerges as a central regulator of the various activities of TORC1. During the ni...
Biological and systemic erythematous lupus: novelties and perspectives (Biologics and systemic lupus erythematosous: new insights and perspectives]
Systemic lupus erythematosus is a complex autoimmune disease that remains challenging to treat. Recent advances in the understanding of the pathogenesis of SLE pave the way for the evaluation of biologic medicine. The most promising therapeutic targets in SLE are those that interfere with B cells co...
The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies.
SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has posed a worldwide challenge to human health as no effective treatment is currently available to combat the disease. Its severity has led to unprecedented collaborative initiatives for therapeutic solutions against COV...
Role of glutathione in macrophage activation: effect of cellular glutathione depletion on nitrite production and leishmanicidal activity.
We have examined the effects of two agents depleting the intracellular pool of glutathione (GSH) on macrophage activation induced by IFN-gamma + LPS, as measured by nitrite production and leishmanicidal activity. Diethylmaleate (DEM), which depletes intracellular GSH by conjugation via a reaction ca...
A therapeutic approach focusing on the conditional effects of drugs
‘titrebSummary’/titreb The hedonic and reinforcing properties of drugs are linked to their interaction with cerebral dopaminergic systems. All drugs lead to an increase of dopamine in the bark of the accumulating nucleus, a brain region which coexpresses the receptors of indiceb1 ‘/indiceb (rd b1’/i...
Effects of glucocorticoids and sympathomimetic agents on basal and insulin-stimulated glucose metabolism
The mechanisms responsible for glucocorticoid-induced insulin resistance remain unclear. Glucocorticoids show several interactions with the sympatho-adrenal system which may contribute to this decrease in insulin sensitivity: they enhance the synthesis and actions of catecholamines, but abolish insu...
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor cells can have pro- as well as antitumorigenic effects. Her...
Cutaneous leukocytoclastic vasculitis associated with letrozole.
Aromatase inhibitors are increasingly used in the treatment of early and metastatic breast cancer. They can produce various skin adverse effects but are only rarely associated with cutaneous vasculitis. We report the first case of cutaneous vasculitis clearly associated with the use of aromatase inh...
Subutex ® a drug, but what is a drug? Outline of a semiotic anthropology of psychotropic drugs
Opioid Alternative Treatment (TSO) was introduced in France in the mid-1990s in a controversial context. The pharmaceutical laboratory found it difficult to obtain a marketing authorisation for BHD in the French health and political situation at the time. France is changing its paradigm in the care...
Selective and directional production of prostaglandins in the endometer
Prostaglandins (PG) are involved in several processes and a good balance in their relative production is important for cyclicity and fertility in both cattle and humans. The main PG produced in the endometer are PGE2 and PGF2α. Their action is regulated at the level of biosynthesis, catabolism and s...
Targeting Cancer Stem-like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma.
Plasticity in cancer stem-like cells (CSC) may provide a key basis for cancer heterogeneity and therapeutic response. In this study, we assessed the effect of combining a drug that abrogates CSC properties with standard-of-care therapy in a Ewing sarcoma family tumor (ESFT). Emergence of CSC in this...
Feline Epilepsy: An update
ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗ
Logical analysis of the respective influence of 3 experimental variables using a diagram by L. Carroll. Application of this method to a clinical trial of 2 forms of Noveril
peer reviewed The analysis of the results of a double-blind randomized cross-over clinical trial of dibenzepin was systematized to show the relation between the experimental variables and the effects measured. The suggested method of analysis is based on logic and employs a diagram by L. Carroll.
Pharmaceutical care for elderly people with tuberculosis and resistance to treatment
Os riscos em idosos com tuberculose são elevados, por isso a assistência farmacêutica nesse tipo de paciente é importante, sendo o farmacêutico o profissional mais capacitado para suporte de intervenções medicamentosas quando a resistência ao tratamento. O estudo teve como objetivo relacionar a atua...
Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes.
OBJECTIVES: Capillary rarefaction is a hallmark of untreated hypertension. Recent data indicate that rarefaction may be reversed by antihypertensive treatment in nondiabetic hypertensive patients. Despite the frequent association of diabetes with hypertension, nothing is known on the capillary densi...
Adherence to and effectiveness of highly active antiretroviral treatment for HIV infection: assessing the bidirectional relationship.
BACKGROUND: It is well established that high adherence to HIV-infected patients on highly active antiretroviral treatment (HAART) is a major determinant of virological and immunologic success. Furthermore, psychosocial research has identified a wide range of adherence factors including patients' sub...
Rapid sample pre-treatment prior to GC-MS and GC-MS/MS urinary toxicological screening.
Drug screening is an important issue in clinical and forensic toxicology. Gas chromatography coupled to mass spectrometry (GC-MS) remains the gold standard technique for the screening of unknown compounds in urine samples. However, this technique requires substantial sample preparation, which is tim...