N-3 very long chain polyunsaturated fatty acids (n-3 VLC PUFA) are essential for human health but are almost exclusively present in seafood. Thus, in a strategy of diversification of n-3 VLC PUFA sources for human, the aim of this thesis was to better understand the cellular mechanisms that may expl...

‘titrebSummary’/titrebThe asymmetrical nature of brain organisation for cognition continues to fascinate the public and mobilise researchers. The possibility that this asymmetry may differ between men and women, and the search for underlying factors, has recently shaken research into the role of sex...

Chronic lymphoid leukaemia (CLL) is the most common adult form in the Western world. Patients affected have a very varied clinical pathway. It is important to identify new prognostic markers and therapeutic targets in order to optimise both patient care and treatment. A previous study by our group s...

Despite a number of studies regarding the association of endogenous sex steroid hormones with mortality in men, the results remain controversial and could depend on the characteristics of the subjects and the cause of death. Using the data from the prospective ThreeCity cohort study set-up in France...

‘titrebSummary’/titrebFor discussing the history of the pharmaceutical, historian or economist industry often use the concept of ‘innovation regime’. This article discusses it on the basis of an analysis of the research and production practices of the German industry in the interwar period. The traj...

To discuss the history of the pharmaceutical, historian or economist industry often use the concept of “innovation regime”. This article discusses it on the basis of an analysis of the research and production practices of the German industry in the interwar period. The trajectory of a particular cat...

The medical uses of estrogenes, progesterone and their synthetic analogues have been the cause of numerous public controversy in the United States, questioning their iatrogenic effects and the role of producers, their influence on prescribing practices and regulation. This article compares the ditil...

International audience The medical uses of female sex hormones and their synthetic analogs have, in the United States, been the focus of regular public debates around their iatrogenic effects and the influence of pharmaceutical firms on prescription patterns and regulatory interventions. This paper...

Hormonal contraceptives are widely used tools for managing primate populations in zoos, but their control is currently a major problem. Indeed, their impact on cycles, health and behaviour is not well known, and their effectiveness seems to be uneven. The aim of this study is to establish a biologic...

The incidence of metabolic diseases has steadily increased in recent decades reaching epidemic proportions. It is conventionally accepted that their main cause is related to a diet rich in fats and sugar and/or a sedentary lifestyle that can be aggravated by certain genetic polymorphisms. Chemical c...

The crucial role of sex steroid hormones in male reproductive and non-reproductive functions are well documented. Recent evidences suggest that testosterone is also involved in neuroprotective functions in the adult male brain in both pathophysiological and physiological conditions. In the nervous s...