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Evaluation of the calcium channel TRPA1 as a potential therapeutic target in the pathogenesis of Alzheimer's disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively affects cognitive functions and memory. AD brains are characterized with the extracellular deposition of amyloid-β (Aβ), a peptide that aggregates in structures named “senile plaques”. However, it has been recognized that ol...
Consequences of genetic and pharmacological blockade of A2A receptor in a AD-like Tau pathology transgenic mouse model. Relationship with neuro-inflammatory processes
Population ageing is a major risk factor for dementia, the most prevalent being Alzheimer disease (AD). AD is a neurodegenerative disorder characterized by a progressive cognitive decline, notably impacting memory functions. Its formal diagnosis is based on the post-mortem examination of AD patients...
Maladie d’alzheimer et dispositifs d’assistance et/ou de surveillance électronique
Learning Multimodal Digital Models of Disease Progression from Longitudinal Data : Methods & Algorithms for the Description, Prediction and Simulation of Alzheimer’s Disease Progression
This thesis focuses on the statistical learning of digital models of neurodegenerative disease progression, especially Alzheimer's disease. It aims at reconstructing the complex and heterogeneous dynamic of evolution of the structure, the functions and the cognitive abilities of the brain, at both a...
Alzheimer and non-verbal communication
La maladie d’Alzheimer ou apparentée a pour effet d’effacer progressivement les codes et les conventions nécessaires à la communication digitale, bousculant de ce fait les capacités langagières des personnes atteintes. Familles et soignants se retrouvent désemparés, incapables de communiquer avec le...
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Doctoral fellowships and thesis prize of the “Médéric Alzheimer Foundation”
La Fondation Médéric Alzheimer, soucieuse de soutenir les jeunes chercheurs en sciences humaines et sociales ou en santé publique qui ont choisi de consacrer leur thèse de doctorat à la maladie d’Alzheimer et aux maladies apparentées, attribuera en 2016 quatre Bourses doctorales d’un montant de 10 0...
Call for applications: Doctoral fellowships Fondation Médéric Alzheimer
La Fondation Médéric Alzheimer soutient les jeunes chercheurs en sciences humaines et sociales ou en santé publique qui ont choisi de consacrer leur thèse de doctorat à la maladie d’Alzheimer et aux handicaps cognitifs liés au vieillissement. Elle attribuera en 2019 quatre Bourses doctorales d’un mo...
Physiological and pathological ageing of nervous control of respiration: study in wild and transgenic mice
New issues are emerging in the field of Health care due to ageing of the population and the alarming development of Alzheimer’s Disease (AD). In healthy or pathological living being, very few studies are dealing with the ageing of the respiratory nervous control, in spite of the crucial role of resp...
Chronic diseases. Towards the 3th Medicine
Education and training in the context of alzheimer and related diseases: ‘ibview of a gerontopsychiatrist’/bubage with ploton leaf’/bbprofessor emerite in gerérontology, University of Light, Lyon ii
`titrebEDUCATION AND TRAINING IN THE CONTEXT OF ALZHEIMER'S DISEASE AND RELATED CONDITIONS : A GERONTOPYSCHIATRIST’S POINT OF VIEW`/titreb The exploration of the learning potential (and its limits) of aged people suffering from Alzheimer’s Disease and related conditions enables identification of app...
Alzheimer’s disease and related syndromes: diagnostic and therapeutic recommendations
Neuropeptides and Neprilysins : role in memory in Drosophila
During my PhD, I studied neprilysins, proteinases known to degrade small neuropeptides, in particular mammalian amyloid-β peptides (Aβ). During Alzheimer’s disease, Aβ peptides aggregate to form toxic plaques. It has been shown that neprilysins expression modulates toxic effects of Aβ on memory in m...
Identification of the dispositional, cognitive and environmental determinants of subjective age with advancing age.
Given the exponential increase in the number of people aged 60 and more, the identification of the factors associated with the reduction of chronic disease risk and the maintenance of quality of life with advancing age is a major public health concern. Evidence accumulates about the implications of...
Summon the animals of yesterday with the animals of today. Sociological reflections on the integration of animals into the worlds of care
Inhibiting processes in Alzheimer’s disease and fronto-temporal dementia
Neural correlations of memory acquisition and consolidation in Alzheimer’s disease and isolated memory disorder
The cultural dimension in the context of the neuropsychological assessment of Alzheimer’s disease among the Lebanese population
Characterisation of Transgenic C. elegans Alzheimer models, expressing the Human Tau protein in their GABAergic motonones
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by two hallmarks: extracellular plaques composed of amyloid-β (Aβ) deposits and intraneuronal accumulation of hyper and abnormal phosphorylated tau, also called neurofibrillary tangles (NFT). Despite many decades of research, the...
Behavioural disorders in the frontal variant of the FTD: how can they be explored?
`titrebBehavioral troubles in bv-FTD: how to explore them?`/titrebPsychobehavioral disorders are core features of dementia. They have consequences on patients’ treatments and outcome. They are particularly frequent for frontal (or behavioral) variant of frontotemporal dementia (fv-FTD). In 2011, an...
Go wrong, go well, go better, go better, go well, go better: three ways of living with Alzheimer’s disease
The implicit motor learning use as a therapeutic tool in frail elderly people
To write, take, walk, talk is a part of our daily. Our motor ability is used to change depending on our environment and our skill, acquired thanks to our experience, learnings, and according to our age. We strive to find optimal solutions, to be more performants, more efficient. But we must be able...
The psychiatry of the elderly and neurodegenerative conditions: towards reintegration or break-up?
`titrebElderly psychiatry and neurodegenerative diseases: toward reintegration or breaking?`/titrebTo fasten Alzheimer’s disease and dementia or major cognitive disorders to neurology questions our representation of mental disease and not only of elderly psychiatry. Change from psychiatry to mental...
Misalignment at opening of a sequence of disagreement in consultation Alzheimer
It is customary for an Alzheimer patient to be accompanied by a family member or companion during appointments with his or her physician. This three-way consultation allows the doctor to interview the patient while the companion witnesses the interaction, having the opportunity to then confirm, modi...
Nutrition and brain ageing: a complex relationship
`titrebDIET AND CEREBRAL AGEING, A COMPLEX RELATIONSHIP`/titreb `alinea/b The relationship between diet and cerebral ageing is complex : on the positive side, a balanced diet could postpone cognitive decline but, on the negative side, dementia reflects on the nutritional status of older people and t...
Pathophysiological role of Pyk2 in the nervous system
Proline-rich tyrosine kinase 2 (Pyk2) is a calcium-dependent non-receptor tyrosine kinase of the focal adhesion kinase (FAK) family, enriched in forebrain neurons. In this thesis, I studied Pyk2 in neuropathological conditions in vivo, using total or conditional knock-out mice. Pyk2 deficit in the h...