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Anti-infectious properties of Toll-like receptor agonists in association with antibiotics in the treatment of lung infections
Bacterial infections of the respiratory tract constitute a major cause of death worldwide. Given the constant rise in bacterial resistance to antibiotics, treatment failure is increasingly frequent. In this context, innovative therapeutic strategies are urgently needed. Stimulation of innate immune...
“The book of properties of things, translation by Jean Corbechon of Barthélemy l’English book” (collar with Cécile Martini)
Arc’s contributions to the Étang de Berre (French Mediterranean coast). Hydrology, physical and chemical traits
Freshwater inflow from the River Arc to the Etang de Berre (French Mediterranean coast) : hydrology, physical and chemical characteristics) . The influence of the Arc River on the ecology of Etang de Berre (a brackish lake located an the French Mediterranean coast) , of which it is the main tributar...
Development of advanced methods for super-resolution microscopy data analysis and segmentation
Among the super-resolution methods single-molecule localization microscopy (SMLM) is remarkable not only for best practically achievable resolution but also for the direct access to properties of individual molecules. The primary data of SMLM are the coordinates of individual fluorophores, which is...
Photoaging and skin cancer : unraveling the conformational parameters important for (6-4) DNA photoproduct formation
Exposure of DNA to solar UV light induces chemical modifications on its nucleic bases that are responsible for photoaging and skin cancer. Two major DNA photoproducts class exist: cyclobutane and (6-4) adducts. The latter is intrinsically more mutagenic than the cyclobutane adduct and therefore pote...
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In vitro enamel subsurface lesions : characterization and treatment
White spot lesion is the subsurface hypomineralization of enamel indicating the 1st stage of dental caries development. Early detection of incipient dental caries before it reaches the stage of cavitation offers an opportunity for effective dental care. The objectives of this study were to strengthe...
Theoretical and practical aspects in non parametric estimation of the conditional density with functional data
In this thesis, we consider the problem of the nonparametric estimation of the conditional density when the response variable is real and the regressor is valued in a functional space. In the rst part, we use the double kernels method's as a estimation method where we focus on the choice of the smoo...
Characterization of a novel candidate epigenetic regulator of pluripotency
Embryonic stem cells (ES cells) are an essential tool for biomedical research. They have the particularity to multiply indefinitely while keeping their stemness properties, and the incredible ability to generate all cell types of the body. These characteristics open up new perspectives for regenerat...
LA CONJONCTION MÊME SI N'EXISTE PAS !
In this paper, we reject the usual definition of même si (even if) as single conjunction and meaning as ‘concessive' one. Même si share similar syntactico-semantic properties with ‘conditional', but not ‘concessive', (class of) conjunctions. In fact, même si is a conjunctive phrase including the si...
Engineering of Lactic Acid Bacteria strains modulating immune response for vaccination and delivery of therapeutics
The use of Lactic Acid Bacteria (LAB), such as Lactococcus lactis (LL), as DNA delivery vehicles represents an interesting strategy as they are regarded as safe. Wild type (wt) LL or recombinant invasive LL, were able to trigger DNA expression by epithelial cells both in vitro and in vivo. However,...
Study and local classification of hexagonal harmonic 3-webs
Classically, in web geometry, we consider families of foliations modulo local diffeomorphisms and we study them by differential invariants of the pseudo-group of diffeomorphisms. In this work we introduce the notion of harmonic foliations and hexagonal harmonic 3-webs, we develop basic properties, p...
Electrical studies in fractured média
Les roches fracturées ont un rôle prépondérant sur notre mode de vie, car elles peuvent contenir des ressources précieuses, telles que de l'eau ou des hydrocarbures, ou sont le lieux de transport de contaminants et de polluants indésirables. Ainsi, la capacité de modéliser et de caractériser les mil...
Anchored solutions in robust combinatorial optimization
If the instance of an optimization problem changes, an initial solution may become suboptimal or infeasible. It is then necessary to compute a new solution, but it is also desirable to keep some decisions from the initial solution unchanged. In this thesis we propose the anchoring criterion to favor...
Chapter 3 Bone: morphology, structure and chemical composition
Regulation of quiescence and migration of T lymphocytes by Fam65b, a new transcriptional target of F0X01
T cells continually sense numerous soluble and cellular signals, which determine their behavior and differentiation pattern. At the steady state, lymphocytes properties rely on a specific network, in which FoxOs transcription factors play a central role. Indeed, FoxOs-induced transcriptome is involv...
Study of the mechanical and electrical properties of biological systems at the nanonscale
The atomic force microscope (AFM) is a powerful tool for the study of biological systems. In this work, I was interested in the correlation of four types of microscopies: the atomic force microscopy, the high resolution fluorescence microscopy, the electron microscopy and the kelvin force microscopy...
Development of a new design method for the cross-section capacity of steel open sections at high temperatures
At high temperatures, steel suffers from great losses in strength and stiffness. Different design methods must therefore be considered to predict the resistance of steel in the exceptional situation of fire. Current standards propose simplified methods to predict the resistance of steel at high temp...
Function spaces on quantum tori and their applications to pseudo-differential operators.
This thesis is devoted to the study of the analysis on the spaces hpc(Rd,M), the local version of operator-valued Hardy spaces studied by Tao Mei. The operator-valued local Hardy spaces are defined by the truncated Littlewood-Paley g-functions and the truncated Lusin square functions associated to t...
Can szaibelyite replace asbestos? Preliminary study of solubility in a similar pulmonary medium.
résumé d'une recherche inédite La szaibélyite, hydroxypyroborate de formule Mg2B2O5 H2O, possède des propriétés analogues à celles des minéraux fibreux regroupés sous le terme d’amiante (caractéristiques structurales, physicochimiques et thermiques, en particulier sa possible décomposition avec libé...
Regulation of intestinal inflammatory response by cigarette smoke : cellular and molecular characterization in mice
Current hypothesis on the pathogenesis of inflammatory Bowel disease suggests that the disease development implicates a deregulated dialogue between the intestinal flora and components of both the innate and adaptive immune systems in genetically susceptible individuals and under the influence of en...
Role of the PRL-3/PTP4A3 phosphatase in the metastatic process of uveal melanoma
Uveal Melanoma (UM) is a rare tumor that affects around 500 French people each year. Despite a successful treatment of the primary tumor, 50% of patients develop metastasis primarily to the liver in the years following diagnosis. Currently, systemic adjuvant therapy has been unsuccessful for effecti...
Evaluation of portable spectrometers Raman, Infrarouge and Proche Infrarouge for the detection of counterfeit medicines
La contrefaçon de médicaments est un délit qui n'a cessé d'augmenter ces dernières années. Diff érents spectromètres portables ont été proposés sur le marché afi n de permettre une détection rapide des contrefaçons sur le terrain. Les spectroscopies Raman, Infrarouge et Proche Infrarouge présentent...
The participation of the aporoi in the late-republican servile wars and their relationship with the rebel slaves : dominant ideology, popular praxis and civil discords
The participation of free men in the movements led by rebellious slaves sets a complex problem in terms of the importance of the freedom/slavery antinomy in the thinking of the ancient Greeks and Romans. The chattel-slaves, defined as things, were represented as foreigners. The slaves served as the...
Practice in the formulation of cases in psychotherapy
Un cas exemplaire, un cas d'école, un beau cas, un cas de figure, un cas extrême, un cas particulier, un cas épineux, un cas limite ... Les modalités de l'étude de cas sont multiples et expriment le fait que tout raisonnement suivi, toute explication, toute théorie bute une fois ou l'autre sur la né...
Research on Performance Evaluation and Anti-scaling Mechanism of Green Scale Inhibitors by Static and Dynamic Methods
Increasing environmental concerns and discharge limitations have imposed additional challenges in treating process waters. Thus, the concept of "Green Chemistry" was proposed and green scale inhibitors became a focus of water treatment technology. Finding some economical and environmentally friendly...