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A novel Androgen Synthesis Pathway in treatment-REsistant Prostate Cancer
ID629745FromFebruary 28, 2014toJuly 31, 2015FunderEuropean CommissionProstate cancer (PC) is the most prevalent non-cutaneous cancer in men and leads to high morbidity and mortality. Disseminated PC is treated by hormonal treatment in order to block intratumoral activation of the androgen receptor (AR) by 5α-dihydrotestosterone (DHT). Despite this treatment, eventual...Environmental signaling and ovarian diseases susceptibility
ID321745FromAugust 31, 2012toAugust 31, 2016FunderEuropean CommissionIn adult mammals, ovarian function is characterized by regular cyclic changes, which are critical for the egg development, sex steroid hormones production and fertility. These processes depend on the tight regulation of the activity of different ovarian signaling cascades that if altered during crit...A paradigm change in the treatment of blinding ocular diseases
ID879598FromJune 30, 2019toJune 30, 2021FunderEuropean CommissionOcular inflammatory diseases – affecting hundreds of millions of people worldwide – impose a significant medical and economic burden on society and can lead to blindness. Today, corticosteroids are the most common method used to treat ocular non-infectious inflammation of any kind. Rather than treat...Metabolic Networks that Link Longevity to Reproduction in Response to Nutrition
ID647003FromSeptember 30, 2015toSeptember 30, 2020FunderEuropean CommissionIn most western countries, life expectancy is increasing by 3 months a year. As the average age of the population increases, so too does the prevalence of age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegenerative disorders. An essential component of ageing res...Biomarkers and underlying mechanisms of vulnerability to depression
ID629541FromMarch 31, 2015toDecember 1, 2017FunderEuropean CommissionDepression is the leading chronic condition in Europe and fourth leading cause of mortality woldwide. Depression is twice more common in women compared with men, associated with dysregulation of steroid hormones in the HPA-HPG axis, ovarian dysfunction, obesity, and very recently, prenatal stress, b...Restoring tissue regeneration in patients with visceral Graft versus Host Disease.
ID643580FromDecember 31, 2014toDecember 31, 2021FunderEuropean CommissionStem cell regenerative therapies hold great promise for patients suffering from a variety of disorders that are associated with tissue or organ injury. Regeneration relies on tissue or organ-specific stem and progenitor cells, but can also aim at promoting the endogenous repair capacity of the body....Learning in the Space of Dynamical Models of Adrenal Steroidogenesis “LeSoDyMAS”
ID659104FromJuly 12, 2015toJuly 12, 2017FunderEuropean CommissionTo date most successful machine learning techniques for the analysis of complex interdisciplinary data predominantly use significant amounts of vectorial measurements as input to a statistical system. The domain expert knowledge is often only used in data preprocessing and the subsequently trained t...Intra Erythrocyte Dexamethasone in the treatment of Ataxia Telangiectasia
ID667946FromDecember 31, 2015toAugust 31, 2021FunderEuropean CommissionCoordinatorErydel SpaThe main objective of the project is to provide a treatment of the neurological symptoms of patients with Ataxia Telangiectasia (AT), a rare progressively disabling and life-shortening genetic disease for which no therapy is currently available. To achieve this, a pivotal Phase III study will be con...NEXT GENERATION TOPICAL MEDICATION TO TREAT IMMUNE RESPONSES IN ATOPIC DERMATITIS – THE MOST COMMON CAUSE OF ECZEMA
ID885787FromNovember 30, 2019toMay 31, 2020FunderEuropean CommissionTIRmed pharma AB has developed a non-steroid cream that relives itch in Atopic Dermatitis (AD). Itch is an enormous, unresolved symptom in AD, induced by inflammation and skin damage. AD poses a significant burden on societies and patients’ quality of life due to itch, infected lesions, sleep depriv...Consequences of out-group conflict
ID682253FromJune 30, 2016toDecember 31, 2022FunderEuropean CommissionThe aim of this project is to determine the proximate and ultimate consequences of a fundamental but neglected aspect of sociality: out-group conflict. In a wide range of social species, from ants to humans, group members invest considerable defensive effort against individual intruders and rival gr...