Query : fertility
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Defining the mechanism of the dual spindle assembly and alignment in the mammalian zygoteID101031333From1 June 2021to31 May 2023FunderEuropean CommissionThe first embryonic division after fertilization is essential for development of the organism and has to promote the union of the parental genomes. My host lab recently showed that in mammalian zygotes two bipolar spindles form, which first independently congress the maternal and paternal chromosome...
Discontinuities in Household and Family FormationID694262From1 February 2017to31 July 2022FunderEuropean CommissionHousehold, family and fertility changes are key drivers of population dynamics. Discovering and explaining the velocity of these changes is essential to understand the current situation and to provide scientific evidence on our demographic future. DisCont will provide seminal contributions by studyi...
Medical microbots to support new assisted reproduction techniquesID835268From1 November 2019to31 October 2024FunderEuropean CommissionCoordinatorTECHNISCHE UNIVERSITAET CHEMNITZInfertility is a health issue with sociological and psychological implications that affects approximately 50 million couples worldwide and therefore receives global attention. Among fertility issues, male infertility is diagnosed in about 40% of all cases and the major causes are poor motility of sp...
Sex in malaria parasites – from basic biology to targets for transmission blocking interventions.ID788516From1 September 2018to31 August 2023FunderEuropean CommissionSexual development in malaria parasites is critical for disease transmission between infected individuals, and is therefore a major target for the malaria elimination agenda. However, there are currently no effective drugs or vaccines that block parasite transmission to mosquitoes, and we currently...
The Implantable Subcutaneous String Defibrillator, an innovative subcutaneous cardioverter defibrillator for a new paradigm in cardiac rhythm management.ID790070From1 November 2017to28 February 2018FunderEuropean CommissionSudden Cardiac Arrest (SCA) is a life-threating heart condition and one of the most common causes of death in developed countries claiming more than 350,000 lives per year in Europe2. There are currently two different implantable technologies to prevent SCAs: 1) Transvenous Implantable Cardioverter-...
How elephants grow oldID648766From1 January 2016to31 December 2021FunderEuropean CommissionCoordinatorTURUN YLIOPISTOThe ageing population structure of most European countries has major health, economic and social consequences that lead to a need to better understand both the evolutionary limitations of deferring ageing, as well as the mechanisms involved in growing old. Ageing involves reduced fertility, mobility...
New integrated methodology and Tools for Retrofit design towards a next generation of ENergy efficient and sustainable buildings and DistrictsID680474From1 September 2015to31 August 2018FunderEuropean CommissionCoordinatorINTEGRATED ENVIRONMENTAL SOLUTIONS LIMITEDNewTREND seeks to improve the energy efficiency of the existing European building stock and to improve the current renovation rate by developing a new participatory integrated design methodology targeted to the energy retrofit of buildings and neighbourhoods, establishing energy performance as a key...
Deciphering the roles of chromatin modifiers in germline agingID654853From1 May 2015to30 April 2017FunderEuropean CommissionFaithful transfer of genetic material is critical for the success of all cell divisions. Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes. This can lead to cancer in mitotic cells, and in the female germline...
A slow release insemination that doubles the success rate of the most common first line treatment of infertility.ID882909From1 December 2019to29 February 2020FunderEuropean CommissionInfertility impacts 25 million European citizens and 90 million couples globally (1 in 6 couples). Europe’s total fertility rate is among the lowest in the world, at 1.5 children per woman, a figure that is expected to decrease further to 1.2 by 2030 – making it a critical public health issue.Typica...
Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammalID794087From1 June 2018to9 August 2020FunderEuropean Commission"European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of ""biological age"", and in particular its genetic determinants. It is now established that longevity insurance genes such a...
Healthy Apples Research: Valuing Environmental Sustainability of TopsoilID796790From4 March 2019to23 October 2021FunderEuropean CommissionThe HORIZON 2020 societal challenges highlight the need to innovate on agricultural practices that increase agroecosystem resilience and foster efficient use of available water and nutrients. This is particularly relevant for baby food production systems since there are stringent European regulation...
Intra and inter-generational effects of heatwaves on sexually selected traits and reproductive successID101027067From1 December 2021to30 November 2023FunderEuropean CommissionHeatwaves are a current problem faced by society and are increasing in frequency and intensity under ongoing climate change. While many climate change studies exist, those investigating the consequences of heatwaves are scarce, especially in relation to reproduction. The extreme temperatures experie...
Differential demographic behaviour by education and its links with the reproduction of educational inequalities in EuropeID846478From2 January 2020to1 January 2022FunderEuropean CommissionIn the last decades, social inequalities within countries and the rise in socio-economic differences between European countries have been an increasing policy concern. Education plays a chief role as a resource to fight poverty and to ensure greater social and territorial cohesion, within and across...
Portable Characterisation of Sperm MotilityID727774From1 April 2017to30 September 2018FunderEuropean CommissionBased on an ongoing ERC project on characterising and studying the motility of highly-idealised, model micro-swimmers, we have built and validated a first-generation portable prototype device for assaying accurately bull sperm motility. To move to a more advanced prototype requires integrated softwa...
Setting a standard for personal digital sperm analysisID789952From1 October 2017to28 February 2018FunderEuropean CommissionQS Mobile is a novel clip-on device for smartphones for male sperm analysis. QS Mobile combines microfluidics technology, compact optics & advanced video image analysis to make sperm tests automated, removing the manual labour errors & providing precision & reliability levels comparable to labs. QS...
Family formation decisions and gender attitudes in crisis times: an international, historical and longitudinal comparison.ID657030From1 October 2016to30 September 2019FunderEuropean CommissionCoordinatorCENTRO DE ESTUDIOS DEMOGRAFICOSDuring the last decades, Spain has experienced not only an strong decrease on its fertility levels but also a significant delay in its timing to childbearing, so much so that it has been considered one of the countries with the lowest-low and latest-late fertility in the world. This research aims to...
Organic Knowledge Network ArableID652654From1 March 2015to28 February 2018FunderEuropean CommissionCoordinatorINTERNATIONAL FEDERATION OF ORGANIC AGRICULTURE MOVEMENTS EUROPEAN UNION REGIONAL GROUPThe overall aim of the thematic network ‘OK-Net Arable’ is to improve the exchange of innovative and traditional knowledge among farmers, farm advisers and scientists to increase productivity and quality in organic arable cropping all over Europe, in order to satisfy future market demand. To achieve...
Pregnancy and Reproduction Organ-on-a-chip ModelsID748903From1 July 2017to30 June 2019FunderEuropean CommissionPreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases.Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to mu...
Multi-actor and transdisciplinary development of efficient and resilient MIXED farming and agroforestry-systemsID862357From1 October 2020to30 September 2024FunderEuropean CommissionMIXED is a multi-actor project to drive the development of European Mixed Farming and Agroforestry Systems (MiFAS) that optimize efficiency and resource use, reduce GHG emissions, and show greater resilience to climate change by considering agronomic, technical, environmental, economic and social ad...
OvaRenew as a first-line therapy in impaired egg quality treatmentID743905From1 December 2016to31 May 2017FunderEuropean CommissionPotenza Medica Ltd. is specialised in the development and commercialisation of innovative fertility products. Our solution is tackling one of the deepest human needs-reproduction. With OvaRenew as a first-line therapy in ovarian infertility, we intend to grab business opportunity to be the first in...
Edaphic adaptation in barley wild relatives and its transfer to the domesticateID949873From1 February 2021to31 January 2026FunderEuropean CommissionWild relatives of domesticated plants have long been recognized as important sources of beneficial traits for crop improvement. Having diverged millions of years ago from the domesticate, they have evolved adaptations to more diverse habitats, potentially representing a much wider genetic diversity...
The formal demography of kinship and familyID788195From1 June 2018to31 May 2024FunderEuropean CommissionEvery individual is connected to a network of kin --- her/his family in the broad sense of that term --- that develops and changes as the individual ages. Family network affect demographic, economic, and health-related aspects of life and society. Despite its undeniable importance, remarkably littl...
Recessions, labour-market uncertainty and healthID705140From1 March 2016to28 February 2018FunderEuropean CommissionMy postdoctoral project for the Marie-Sklodowska-Curie fellowship deals with recessions and health. The aim of the proposal is to provide a comprehensive analysis of how individual health is affected (both in the short and in the long-run) when recessions cause uncertainty on the labour-market. To a...
Unexpected connections between a phagocytic machinery and mammalian fertilizationID835243From1 October 2019to30 September 2024FunderEuropean CommissionFertilization is essential for a species to survive. Mammalian sexual reproduction requires the fusion between the haploid gametes sperm and egg to create a new diploid organism. Although fertilization has been studied for decades, and despite the remarkable recent discoveries of Izumo (on sperm) a...
The City Rising: Inequality and Mobility in a Growing Metropolis of the 19th CenturyID101044546From1 January 2023to31 December 2027FunderEuropean CommissionThe rising industrial metropolises of the 19th century faced a series of timeless challenges: the disruptive effects of new technologies, the integration of new immigrants, the threat of epidemics. In this project we study, with the use of novel, high-quality, high-frequency individual-level archiva...